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Director, Revenue Forecasting and Commercial ; North America

Job in Boston, Suffolk County, Massachusetts, 02298, USA
Listing for: Rhythm Pharmaceuticals, Inc
Full Time position
Listed on 2026-01-01
Job specializations:
  • Finance & Banking
    Financial Manager, VP/Director of Finance
  • Business
    Financial Manager, VP/Director of Finance
Job Description & How to Apply Below
Position: Director, Revenue Forecasting and Commercial Performance (North America)
Company Overview

Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients and their families living with rare neuroendocrine diseases. We develop medicines for previously untreatable or undertreated diseases and provide meaningful support for healthcare providers and patients and their families. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need.

Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together.

Opportunity Overview

Reporting to the Head of Business Insights and Analytics for the North American region Rhythm Pharmaceuticals is seeking a strategic and experienced Director of Revenue Forecasting and Commercial Performance for our rare disease portfolio. The role is to serve as the primary analytics partner for the region for all aspects of financial performance from revenue to operating expenses. This role is pivotal in developing robust, data-driven forecasts, scenario planning, analyzing commercial performance, providing ongoing P&L visibility to leadership, and supplementing analytics to support the commercial success of IMCIVREE in current and future approved indications.

This role will also have a secondary reporting relationship with the Vice President of Financial Planning and Analysis. The ideal candidate will bring deep expertise in pharmaceutical revenue forecasting, finance, P&L reconciliation, analytics, and a strong understanding of rare disease markets, and a collaborative mindset to work across multiple teams including Commercial, Finance, and Medical.

Responsibilities and Duties

• Own and lead U.S. and Canadian revenue forecasts for current and future indications and products

• Lead annual, quarterly and rolling forecasts for revenue, patient projections, and product uptake across the U.S. and Canada for Rhythm’s approved and future rare disease indications.

• Build and refine complex forecast models incorporating epidemiology data, primary and secondary data, market research, and competitive intelligence.

• Drive continuous improvements in forecasting methodology, tools, and processes, leveraging advanced simulation models and sensitivity analyses to drive accuracy and stakeholder buy-in.

• Present forecast assumptions, risks, and opportunities in well-structured presentations to support alignment and presentation to senior leadership.

• Liaise with International organization to ensure general consistency in forecast approach, where appropriate.

• Stay current with competitive landscape and emerging market dynamics within rare diseases to inform forecast adjustments.

• Support strategic planning, new indication launches, and business development initiatives through scenario modeling and strategic forecasting.

Financial Performance Management

• Drive the Financial Performance Management process for North America
- Operating Expense Budgeting & Forecasting

* Deliver financial and operational support for planning, budgeting, accruals, and forecasting activities to the North America region and department leaders on both monthly and quarterly cycles. Ensure active engagement of participants within appropriate timelines and adherence to corporate budget guidance and targets.
- Be the subject matter expert of the financial planning tool (Adaptive) for North American team
- Financial Performance Management

* Track and communicate actual results compared to budget and forecast to North America Leadership team, identifying trends and recommending actions to improve results

* Ensure budgetary compliance through actual variance analyses, vendor dashboard reviews, and purchase order review and management

* Development and enhancement of standard financial reports for monthly and quarterly reviews with North American Leadership

Additional Business Insights and Analytics Support

• Supplement Business Insights and Analytics peers to provide visibility on the health of the business and opportunities for…
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