Senior Director, Financial Planning & Analysis - Commercial

Vertex is growing at a rapid pace with exciting opportunities for motivated professionals who want to contribute to our mission to invest in scientific innovation to create transformative medicines for people with serious diseases. Our Finance function plays a critical role in delivering onthis mission by shaping strategy, enabling informed decision making, andprovidingdeep business insight to support value creation across the enterprise.

The Senior Director of Commercial Finance is a senior leader within theUSCommercial Finance organization and serves as the primary strategic business partner to the US Commercial Vice President and Business Unit Lead.

This leader will partner with the BU Lead todevelop options andguideresource allocation to balancegrowthandprofitability. This highly visible role leads a team responsible for strategic financial management,revenue forecasting, analytics,investment management,and value creation across the business.

• Serve as the finance business partnerto the US Commercial Vice President and Business Unit Lead, leading strategic decision support and shaping long term commercial strategy and execution

• Influence senior executives across Commercial, Medical, Human Resources, Global Finance, and Corporate functions to align financial plans with enterprise goals.

• Anticipate market, competitive, and regulatory dynamics andprovideactionable insights that guide commercial strategy and resource allocation.

• Lead the annual budget, long range planning process, and monthly forecasting cycles for the USCommercialBU, ensuring integration with global planning frameworks.

• Oversee USrevenue and operating expense management and drive analytical rigor and scenario planning to support portfolio optimization and launch readiness.

• Identify value drivers and enterprise risks and develop innovative, data driven solutions to enable profitable and sustainable growth.

• Lead and develop a high performing team with capabilities aligned to Vertex leadership behaviors and culture.

• Build a culture of accountability, operational excellence, and continuous improvement across the Commercial Finance organization.

• Partner with HRon workforce planning and organizational design to support the growth of the US Commercial business.

• Partner with Global Commercial Finance, Accounting, Tax,and Investor Relations to strengthen financial systems, processes, and communication.

• Drive alignment during key business cycles ensuring readiness for launches, lifecycle management, and competitive or market shifts.

• Represent US Commercial Finance in enterprise forums providing strategic, data driven perspectives that influence business direction.

• Expert financial modeling, valuation, analytics, and scenario planning capabilities.

• Strategic thinker with the ability to translate complex information into useful insights for senior leaders.

• Exceptional executive communication and presentation skills.

• Ability to lead through ambiguity, drive organizational change, and innovate in a fast paced environment.

• Deep business acumen and understanding of the biotechnology market and commercial strategy.

• Demonstrated ability to lead teams and foster an inclusive,development oriented culture.

• Expertise with Excel and PowerPoint and working knowledge of Hyperion or similar planning tools.

• Bachelor's degree in Finance, Accounting, ora relatedfieldrequired. Master of Business Administration or other advanceddegreestrongly preferred.

• Fifteen or more years of progressive finance experience in commercial, FP&A, or strategic roles including experience supporting senior executives or an equivalent combination of education and experience. Demonstrated success leading financial strategy in a complex and highly regulated environment.

• Extensive experience in drug development, commercialization, launch planning, pricing, reimbursement, and USmarket access.

• Proven ability to influence executives and lead enterprise level initiatives.

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities…