HEOR Modeling Director

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Vertex is seeking a talented and motivated individual with the desire to be part of a highly innovative company aimed at transforming the lives of people with serious diseases, their families and society. The role is as a Director within the Modeling Center of Excellence (CoE), a designated group within the HEOR team that provides strategic and technical modeling support to HEOR, Market Access & Pricing, and the broader commercial organization.

The main responsibility of the Director will be to lead the team that supports the HEOR disease/asset teams in developing health economic models, including models that will provide the foundations for HTA submissions, as well as early models to inform evidence generation needs. The Director will set the direction for modeling strategy across one or more therapeutic areas or pipeline assets.

The Director will provide input into global product value strategy and tactics as well as input to design and interpretation of post-hoc clinical trial analyses and evidence generation studies that relate to economic models. The role has flexibility to be in-person, hybrid, or remote.

• Set the direction for modeling strategy across one or more therapeutic areas or pipeline assets
• Provide leadership and support to the HEOR Modeling team as they develop and roll out economic models to support product value strategy
• Lead the development of global cost-effectiveness and budget impact models, and associated materials. The work may involve both in-house "hands-on" development of models (de novo programming) as well as management and quality assurance and validation of work conducted by external vendors
• Conduct model trainings and provide support to regional teams in local adaptation process and development of HTA submissions, as well as continued support during negotiations with reimbursement authorities
• Provide thought leadership on economic modeling to support development of strategic plans and evidence generation activities
• Provide input into design and interpretation of evidence generation studies needed to support economic models
• Provide subject matter expertise/knowledge to cross‑functional partners to support understanding and appropriate application of relevant HEOR evidence in support of access/reimbursement
• Present research findings at scientific congresses, participate in development of high‑quality publications for peer‑review

• Advanced degree in health economics or a related discipline (such as mathematics, statistics, economics, epidemiology)
• Typically requires 10 years of relevant experience in health economics and outcomes research, or the equivalent combination of education and experience
• Preference for previous supervisory/management experience
• Extensive experience designing and developing health economic models; preferred experience in modeling work to support HTA submissions and negotiations
• Excellent communication skills, strong oral/written presentation skills
• Ability to manage complexity and ambiguity in a highly matrixed work environment
• Ability to navigate and be successful in a fast‑paced environment

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The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job‑related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market‑leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week‑long company shutdown in the Summer and the Winter), educational assistance programs including student…