Scientific Advisor - ADME Project Leadership Biologics

Overview

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees work to discover and bring life-changing medicines to those who need them, improve disease understanding and management, and give back to communities through philanthropy and volunteerism. We’re looking for people who are determined to make life better for people around the world.

Our diverse ADME team is seeking a dedicated and enthusiastic scientist interested in the discovery and clinical development of medicines across multiple modalities, with emphasis on biologics and drug conjugates. If you have a talent for finding creative solutions to complex problems, apply today. We want you on our team.

Our scientifically agile team collaborates with biologists, chemists, engineers and other R&D functions to deliver novel therapies to patients. We support one another through shared learning and mutual responsibility for the enterprise of making medicines. We offer a flexible environment where each team member can optimize productivity while mindful of wellness, enabling growth in careers and in the scientific field in our search for safe and effective medicines.

Please connect with us if you are a motivated and collaborative scientist looking to innovate at the forefront of novel therapies to improve patients’ lives.

Note: A high-quality candidate will demonstrate the following:

Responsibilities / Qualifications

• High learning agility and a keen ability to derive and efficiently test ADME and DMPK hypotheses for novel molecules with particular emphasis on antibodies

• Strong working knowledge in fundamental pharmaceutics, pharmacokinetics and ADME principles especially as they relate to biologics such as antibodies and conjugated molecules

• Understanding of contemporary pharmaceutical regulatory guidance and expectations

• Skills to integrate internal and external laboratory and other experimental resources through high quality scientific associations

• Agile interrogation of diverse data (e.g., in silico, in vitro, in vivo) to derive mechanistic understanding of drug action and performance characteristics

Lilly-ADME seeks a skilled ADME / DMPK scientist who will:

• Lead and innovate in a multidisciplinary collaborative environment with primary responsibility for ADME studies to support preclinical and clinical development of the Lilly portfolio

• Design and implement hypothesis driven studies to answer ADME, PK/PD and clinical pharmacology questions

• Integrate ADME, PK and PK/PD endpoints with discovery biology data to define structure activity- and structure-property-relationships to guide drug delivery and optimization strategies

• Engage, innovate, and collaborate with colleagues and interdisciplinary teams

• Lead the preparation of regulatory communication and documents to support clinical development, new drug applications (NDA and BLA) and line extensions and interact with regulatory agencies worldwide

• Build and foster relationships through coaching and mentorship with fellow scientists

• Possess excellent written and verbal technical communication skills and the ability to lead, guide and influence teams in decision making

Onsite presence (minimum of 3 days/week) at either our headquarters in Indianapolis, Indiana, or our Harborside location in Boston, Massachusetts

Basic Requirements: Ph.D. in Biology, Cellular or Molecular Biology, Biochemistry, Pharmaceutical Sciences, Pharmacokinetics or a related scientific field; experience in the discovery and development of biological-therapeutics highly preferred

• Industry (Pharma/Biotech) experience (1-7 years) in the preclinical evaluation of biologics and/or hybrid modalities, as well as relevant ADME project leadership experience

• Understanding of and experience with immunoassays, and/or LC/MS bioanalytical methodology

• Detailed understanding of pharmacokinetics, ADME and proficiency to communicate theory and concepts clearly

• Experience in drug discovery and development

• Experience with PK/PD modeling and/or bio-distribution

• Ability to balance multiple…