Director, Immunoassay- Biomarker Discovery and Analysis - Neuroscience

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first.

We’re looking for people who are determined to make life better for people around the world.

• Design, development and validation of novel immunoassay-based biomarker methods, as well as applications of these methods for early- and late-phase clinical trials in neurodegenerative diseases, including Alzheimer’s, Parkinson’s, ALS, and rare brain disorders.
• Work with project team leads, including Dr. Kaj Blennow (Vice President of Neuroscience Biomarker Development), and other associates to perform experiments to support both the preclinical and clinical characterization and evaluation of therapeutic molecules through biomarker assay development.
• Assist with the planning and execution of immunoassay method developments, method optimization and validation, as well as sample analyses from cohorts, working with both internal and external partners in complex studies.
• Work directly on-site with methods in the laboratory, and with summarizing and reporting method status of results for internal partners.
• Implement assay validation procedures to deliver high performance biomarker assays for preclinical and clinical sample analyses.
• Collaborate cross-functionally with internal stakeholders (medical, operations, statistics, regulatory) and external partners (CROs, academic institutions) to ensure biomarker validation and successful integration into clinical programs.

• Master’s and/or PhD in Neuroscience, Biochemistry or a related scientific field, with 5+ years of industry, academic, or postdoctoral experience in biomarker development, with recognized expertise in mass spectrometry-based assays for brain diseases.

• Must have an understanding of the principles for antibodies and other affinity-based molecules, for immunoassay design and protein biomarker quantification as well as documented hands‑on experience in immunoassay development and validation for biomarker applications in clinical diagnostics, clinical trials, or preclinical sample analysis.
• Must be technically skilled in the field of qualitative (e.g. electrophoresis techniques, Western blot) and quantitative (e.g. ELISA, MSD, Ella, Simoa) immunoassay‑based analyses.
• Proven leadership in managing and mentoring biomarker research teams in academic or industry settings.
• Experience in ultrasensitive technologies (e.g. NuLISA) and protein separation and purification techniques (e.g. HPLC, immunoprecipitation) is a merit.
• Excellent communication and collaboration skills, with the ability to present to influence both internal and external stakeholders.

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