Senior Clinical Manager - Immunogenetics and Transplant Diagnostics; ITD

Position: Senior Clinical Manager - Immunogenetics and Transplant Diagnostics (ITD)
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The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Job Summary The Immunogenetics and Transplant Diagnostics (ITD) service currently operates across two laboratory sites, one at each academic medical center.  Together, the BWH Tissue Typing and MGH Histocompatibility laboratories provide comprehensive support for solid organ (kidney, heart, lung, liver, pancreas), as well as hematopoietic progenitor cell transplantation and specialized non-transplant diagnostic testing. ITD performs ~60,000 HLA/histocompatibility-related tests per year. Collectively, the ITD laboratories support the combined Mass General Brigham transplant programs which performed more than 750 organ transplants in 2025 alone.

In addition, the MGB ITD Service serves is the Organ Procurement Organization histocompatibility laboratory for OPTN Region 1 and supports nine additional organ and HPCT transplant hospitals across New England.  The senior clinical manager will partner with ITD and MGB Pathology leadership to build a fully integrated immunogenetics laboratory.

Summary Responsible for the daily operation of the lab: staffing, workflow, quality, safety, and regulatory compliance. The position provides daily management and strategic direction for the laboratories. Ensures compliance with all relevant federal, state, and accreditation requirements. This role oversees operations at multiple sites and requires strong management skills, as well as a collaborative approach when working with leaders both locally and within the system.

This is an on-site role, rotating sites as operational and situational needs require.

Does this position require Patient Care?

No

Essential Functions Develops and maintains QA systems to ensure a high level of performance and effective remedial actions to address deviations from performance specifications.

Review performance information, identify opportunities for improvement, and take action to eliminate root causes of performance that do not meet expectations.

Review event management reports, investigate complaints or problems, and analyze data to identify trends or patterns.

Ensure a validation protocol and validation summary is created for new or changed processes.

Assigns, monitors, and supervises work to ensure compliance with laboratory SOPs and applicable federal, state, and accreditation requirements, including health/safety and patient confidentiality.

Ensures the laboratory is prepared for all regulatory reviews and inspections (e.g., TJC, CAP, FACT).Oversees the coordination of clinical trials with principal investigators, study coordinators, quality assurance, and compliance.

Manages computer systems to access clinical laboratory results, produce worksheets on components processed, and perform other data collection or analysis activities.

Conducts interviews and recommends candidates for hiring in accordance with departmental policies to ensure adequate staffing for the laboratory.

Responsible for staff orientation, training, competency assessment, and continuing education, including required department training (safety, infection control, compliance).Qualifications Required Experience The successful applicant must meet CLIA qualifications for general supervisor for high complexity laboratory performing histocompatibility…