Director​/Sr. Director, Clinical Scientist

Damora Therapeutics has hubs in Waltham, MA and in San Francisco, CA but are open to remote hiring.

Damora Therapeutics is an innovative biotechnology company that aims to fundamentally redefine care for people with hematologic disorders. We are advancing a new generation of biologics to treat mutant calreticulin-driven myeloproliferative neoplasms, including essential thrombocythemia and myelofibrosis, where there is significant medical need for new disease-modifying treatments. With multiple programs with best-in-class potential on track to enter clinical development in 2026, our goal is to rapidly bring forward optimized treatments with broad mutation coverage and exceptional convenience to dramatically improve patient outcomes.

We are seeking a Director/Senior Director, Clinical Scientist to play a critical leadership role in the design, execution, analysis, and scientific oversight of our first-in-human clinical trials. This individual will serve as a senior scientific leader and key strategic partner to Clinical Development, Clinical Operations, Translational Science, Regulatory, Biometrics, and Safety, with significant responsibility for study-level strategy, scientific leadership, and cross-functional execution.

The Director/Senior Director, Clinical Scientist will lead the development and authorship of key clinical and regulatory documents; drive ongoing clinical data review and interpretation; contribute to dose-escalation and development strategy decisions; and provide scientific leadership across internal governance and cross-functional forums. This individual will also help establish scalable clinical science processes and best practices as the organization grows.

This role reports to the Senior Vice President of Clinical Research Operations.

• Serve as lead Clinical Scientist on one or more Phase 1 first-in-human dose escalation trials in hematologic malignancies.
• Contribute strategically to the clinical development plan for mCALR targeting antibodies, including study design, dose-escalation strategy, and data interpretation.
• Lead the development, authorship, and review of key clinical and cross-functional documents, including protocols, amendments, IBs, eCRFs, completion guidelines, SAP TLF shells, and regulatory briefing materials.
• Drive dose-escalation and study conduct discussions through real-time review and interpretation of emerging safety, PK/PD, biomarker, and clinical data.
• Provide scientific leadership and recommendations in data review meetings, SRCs, governance forums, and cross-functional team discussions.

• Serve as a core scientific leader across cross-functional program teams, partnering closely with Clinical Operations, Translational Medicine, Regulatory, Biometrics, and Safety.
• Drive alignment and execution across functions to support high-quality and timely study delivery.
• Collaborate with Translational and Preclinical teams to integrate biomarker and mechanistic hypotheses into clinical studies and broader development strategy.
• Proactively identify and address scientific, operational, and strategic risks and gaps.

• Lead ongoing review and interpretation of clinical data, including safety, efficacy, PK/PD, and exploratory biomarkers.
• Develop clear scientific insights and recommendations to inform development strategy and clinical decision-making.
• Contribute to regulatory submissions, health authority responses, internal governance materials, and external scientific communications.
• Support preparation of abstracts, posters, manuscripts, and presentations for scientific…