Senior Manager, Statistical Programming

Senior Manager, Statistical Programming at Tango Therapeutics

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering precision medicine for the treatment of cancer. Our headquarters are located at 201 Brookline Avenue, Fenway, Boston, MA.

We are hiring a Senior Manager, Statistical Programming to lead program activities for oncology clinical trials. The role reports to the Senior Director of Statistical Programming and focuses on study‑specific programming, infrastructure maintenance, and compliance with SOPs to produce high‑quality, timely deliverables.

• Lead statistical programming for clinical trials, ensuring timely, high‑quality deliverables for CSR, publications, presentations, submission reports, and ad‑hoc analyses.
• Develop, validate, and maintain SDTM and ADaM datasets, tables, listings, and figures in accordance with regulatory guidelines.
• Review key study documents, including clinical study reports and regulatory submissions.
• Perform complex statistical analyses and simulations using SAS or R to support trial design and data interpretation; manage macro libraries and templates for efficient data preparation and analysis.
• Provide statistical programming expertise for FDA, EMA, and other regulatory submissions, including electronic submission standards (eCTD).
• Collaborate with biostatisticians, data managers, and cross‑functional teams to define programming strategies, establish timelines, and perform statistical analyses.
• Author or review SDTM and ADaM specifications to ensure compliance with CDISC standards.
• Author and review statistical analysis‑related SOPs.
• Stay current with industry trends, best practices, and emerging technologies in statistical programming and data analysis.

• Bachelor’s or Master’s degree in statistics, life sciences, computer science, or related field with at least 8 years of statistical programming experience.
• Oncology experience preferred.
• Solid understanding of industry standards applicable to clinical study data and regulatory reporting requirements, including eCTD and CDISC implementation.
• Expert level SAS programming (Base, Macro, STAT, GRAPH, SQL) essential; experience with complex assignments, macros, and analyses required.
• Experience with R desirable.
• Extensive experience in clinical studies, including programming and validation of SDTM and ADaM data sets, tables, listings, and figures.
• Experience supporting electronic submissions, including BLA, NDA/sNDA submissions to FDA/EMA preferred.
• Strong analytical and communication skills.

Salary Range

$157,600—$236,400 USD

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.