Senior Manager IT Operations

Seaport Therapeutics is a clinical‑stage biopharmaceutical company advancing the development of novel neuropsychiatric medicines in areas of high unmet patient needs. The company has a proven strategy of advancing clinically validated mechanisms previously held back by limitations that are overcome with its proprietary Glyph

TM technology platform. All therapeutic candidates in its pipeline are based on the Glyph platform, uniquely designed to enable oral bioavailability, bypass first‑pass metabolism, and reduce hepatotoxicity and other side effects.

Seaport Therapeutics is seeking a hands‑on experienced Senior Manager of IT Operations who will not only oversee but actively execute critical IT functions. This role requires a proactive leader who thrives in a fast‑paced biotech environment and is deeply involved in cybersecurity, employee training, and the implementation of AI‑driven solutions. You will work closely with our outsourced Managed Service Provider (MSP) while directly managing day‑to‑day IT operations, troubleshooting issues, and ensuring the security and scalability of our infrastructure.

This position is based in Boston’s Seaport area, with a strong preference for being onsite 4 days per week.

The ideal candidate will embrace a collaborative, innovative culture that embodies our values of service to patients impacted by mental health conditions, with a “we own it” mentality, demonstrating entrepreneurial spirit and technical excellence while fostering teamwork and continuous improvement.

• Actively manage and execute IT Operations, including help desk support, endpoint management, and troubleshooting complex technical problems across corporate and lab environments.
• Implement and maintain cybersecurity controls (MFA, endpoint protection, vulnerability management, incident response) and lead remediation efforts.
• Develop and deliver employee cybersecurity awareness training and onboarding materials.
• Administer Microsoft 365 (Exchange Online, Teams, SharePoint, One Drive) and Okta (SSO/MFA, SCIM automation) with hands‑on configuration and monitoring.
• Coordinate with the MSP on user onboarding/offboarding, software provisioning, and device lifecycle management.
• Provide strategic oversight of all network, cloud (O365/Entra), and security operations, ensuring reliability and compliance while proactively identifying and escalating critical risks.
• Manage the relationship with the Managed Service Provider (MSP), ensuring adherence to service‑level agreements (SLAs), conducting performance evaluations, and overseeing escalation protocols to maintain operational excellence.
• Ensure compliance with IT policies and regulatory frameworks (e.g., SOX, HIPAA, GxP as applicable) through proactive audits and documentation.
• Partner with business units to evaluate, select, and integrate emerging technologies—such as AI/ML solutions and automation platforms—into IT workflows to enhance efficiency, security, and scalability.
• Lead implementation of AI‑driven tools for IT service automation, threat detection, and operational efficiency.
• Assist with vendor management, including selection, contract renewals, and ongoing relationships.
• Maintain accurate inventory of IT assets and software licenses, ensuring compliance with organizational standards and regulatory requirements.
• Partner with the VP, IT & Office Operations on execution of other key projects as they arise while remaining hands‑on in delivery; for example: strategic planning and budgeting processes.

• 6+ years of progressive IT experience, including hands‑on administration of enterprise systems and security tools, with at least two years of direct engagement in an MSP‑partnered environment.
• Bachelor's degree in IT, Computer Science, or related field (or equivalent experience).
• Prior experience supporting biotech, pharmaceutical, or life sciences organizations is strongly preferred.
• Proven expertise with Okta (SSO/MFA, Adaptive Access, SCIM automation), Microsoft 365, Azure, Intune, Defender, Purview, and Entra .
• Demonstrated ability to manage cybersecurity programs and deliver employee training, manage third‑party vendors, service…