Director​/Sr. Director, Information Technology

Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems. Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign.

Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies.

Position Manifold Bio is looking for our first dedicated IT leader to keep our fast, highly technical company secure and scalable as we grow and expand into new space. Manifold builds what it needs: our scientists write their own workflows, our labs run on automation we designed, and our AI team puts new agents to work every week. This is a hands-on role.

You will configure systems yourself, fix what breaks and set the standards that let a fast, highly technical company keep moving. You will not inherit a large team or a finished playbook. You will inherit a technology program already in motion, with single sign-on, a security awareness program and a new network under way, along with runbooks and a working plan, and you will own it from your first week.

You will work closely with our COO, our cloud and data engineers, our AI and computational scientists and our lab automation team. The right person earns trust by being useful first, then makes the case for change in plain language.

Responsibilities Run ITOwn day-to-day IT for everyone across our offices and labs, on Mac and Windows, and be the person people know to call.

Administer our identity platform (Okta), Google Workspace, Slack, device management and the password manager yourself.

Run onboarding and offboarding so access is ready on day one and removed the same day someone leaves.

Keep an accurate record of every device, application, license and owner, and reclaim what goes unused.

Keep conference rooms, printing and the everyday tools working so nobody loses time to them.

Lead security

Own the security program, including phishing-resistant sign-in, endpoint protection, awareness training and phishing tests, incident response and tabletop exercises.

Answer security questionnaires and diligence requests from pharma partners with evidence, not promises.

Hold the line on least privilege for everyone, executives and administrators included.

Keep our cyber insurance requirements met and the evidence ready at each renewal.

Enable science and AIPartner with our cloud and data engineers on AWS identity, access, logging and backup. You set the guardrails, and they run the platform.

Help decide how AI agents get access to data and systems, so the team keeps its pace without exposing the company.

Infrastructure, vendors and budget

Own the network across two floors with our network partner.

Run backup and recovery for cloud, storage and SaaS data, with restore tests on a schedule.

Keep lab instruments connected, patched on a schedule that respects their runs, and recoverable, working closely with lab automation.

Manage IT service providers and contractors against clear service levels.

Build and run the IT budget, recommend when IT should add people or services, and take every purchase through Manifold’s approval process.

Grow the function

Write and maintain the standards and runbooks that let IT scale with the company.

Work with Quality as our programs move toward the clinic, so IT practices are ready for the controls that brings.

Build IT’s…