Executive Director, Excellence & Business Transformation

Executive Director, Performance Excellence & Business Transformation### Executive Director, Performance Excellence & Business Transformation Apply:
Boston, MA:
Full time:
Posted Yesterday:
REQ-30444
** Job Description
**** Role Summary
** The Executive Director of Performance Excellence & Business Transformation for Global Clinical Operations is a senior strategic leader responsible for driving operational excellence, innovation, and transformation across Vertex’s global clinical trial portfolio with a strong focus on technology innovation. This role leads end‐to‐end clinical trials process optimization, oversees global transformation programs, advances digital capabilities (i.e., Clinical Technology Innovations and transformative AI/ML strategies);

leads Business Intelligence and Analytics, develops and implements the strategy for workforce planning and resource utilization and embeds a high‐performance culture that accelerates study delivery while ensuring regulatory compliance and patient safety.  This role reports to the Head of Global Clinical Operations and is a member of the Leadership team.
** Key Responsibilities
*** Lead the creation and execution of a multi‐year transformation roadmap to modernize Global Clinical Operations and elevate operational effectiveness.
* Identify enterprise‐level opportunities to streamline clinical trial planning, site startup, enrollment, data collection, data cleaning, and closeout.
* Drive harmonization and standardization of GCO processes across regions, therapeutic areas, and CRO partners.
* Develop and oversee governance frameworks for clinical transformation initiatives, including prioritization, KPIs, and benefits realization.
* Collaborate with DTE to accelerate adoption of modern clinical technologies
* Embed advanced analytics and predictive modeling to identify enrollment risks, monitor site performance, and optimize operational decision‐making.
* Oversee study and operational metrics, lead dashboard development
* Lead GCO Resource Strategy and allocation
* Drive the identification, implementation, and development of novel site and patient‐facing technologies, including support for end‐to‐end technology deployment and GMDA robotic process automation
* Collaborate with external CROs, vendors, and strategic partners to ensure operational performance, consistency, and efficiency across outsourced studies.
* Build and lead a high-performing Transformation/Operational Excellence team within GCO.
* Oversee change management strategies to ensure global adoption, behavior change, and sustained results.  
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* Education and Experience:

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* * Bachelor’s degree required (Life Sciences, Engineering, Operations, or related field).
* Advanced degree (MS, MPH, PharmD, MBA, PhD) preferred.
* 15+ years of increasing leadership responsibility in Global Clinical Operations, R&D Operations, Clinical Development, or related functions within pharma, biotech, or CRO.
* Proven success driving enterprise transformation and performance excellence initiatives within highly regulated environments.
* Strong track record improving clinical trial cycle times, quality, and operational predictability.
* Experience implementing digital, data, or technology solutions for clinical operations.
** Skills & Competencies
*** Deep understanding of end‐to‐end clinical development processes, regulatory pathways, and operational challenges.
* Strong strategic thinking, portfolio management, and business acumen.
* Exceptional leadership, influence, and stakeholder engagement across global, matrixed environments.
* Data-driven mindset with proficiency in analytics and clinical operations performance management tools.
* Excellent communication skills with the ability to simplify complex concepts for senior…