Scientist II or Senior Scientist, Targeted Proteomics

Scientist II or Senior Scientist, Targeted Proteomics

Join to apply for the Scientist II or Senior Scientist, Targeted Proteomics role at Kymera Therapeutics

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions.

Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit  or follow us on X (formerly Twitter) or Linked In.

• PIONEER:
  We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE:
  We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG:
  We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

• Develop, optimize, and implement targeted proteomics analysis workflows, including automated enrichment strategies, to deliver precise, accurate, and sensitive protein measurements that inform drug discovery and development decisions.
• Collaborate cross-functionally to implement and qualify assays that drive pipeline decision-making.
• Communicate proactively with project teams and within the proteomics function to coordinate sample availability, align timelines, and ensure timely delivery of high-quality results.
• Manage and oversee activities at contract research organizations (CROs), including assay transfer, qualification, and performance monitoring, ensuring adherence to project specifications, timelines, and data quality standards.
• Perform targeted protein mass spectrometry (MS) assays using state-of-the-art LC-MS systems—including nano-LC and Orbitrap platforms—to determine pharmacodynamic (PD) effects, quantify biomarkers, and qualify assays for clinical studies.
• Prepare samples from a wide variety of biological matrices (cultured cells, tissues, plasma, biofluids) from both human and preclinical species using manual and automated bead-based workflows.
• Perform and interpret quantitative proteomics data analyses using software such as Skyline, Max Quant, DIANN, and Spectronaut; generate clear, data-driven reports for cross-functional stakeholders.
• Maintain, qualify, and troubleshoot HPLC and MS instrument performance to ensure reliability and reproducibility.
• Present scientific results and strategic recommendations to internal project teams, senior leadership, and external collaborators in a clear, concise, and influential manner.

• PhD in Biochemistry, Biology, Chemistry, or Chemical Biology with a minimum of 2 years of experience in targeted, mass spectrometry–based proteomics in an industry or startup biotech setting; or BS/MS with 8+ years of relevant experience.
• Broad expertise in targeted proteomics, including:
  • Development and deployment of highly multiplexed and sensitive PRM or MRM stable isotope–labeled peptide assays using DDA and DIA data.
  • Development of immunoaffinity enrichment methods to enhance MS sensitivity.
  • Optimization of protein recovery from complex biological matrices (cells, tissues, plasma, biofluids) and various sample formulations (fresh, frozen, FFPE) across preclinical species.
  • Operation, maintenance, and troubleshooting of nano
    
    LC and Orbitrap MS instrumentation.
  • Quantitative analysis and report generation using Skyline and related proteomics data tools.
• Demonstrated ability to independently analyze, interpret, and clearly communicate targeted proteomics data and conclusions to multidisciplinary teams.
• Proven success…