Scientist - Wolpin-Nowak Lab

The Dana‑Farber Cancer Institute seeks a Laboratory Scientist to focus on next‑generation, translational pathology studies who will work within the Wolpin‑Nowak laboratory ((Use the "Apply for this Job" box below).) as part of the Hale Family Center for Pancreatic Cancer Research () and the Lustgarten Foundation Pancreatic Cancer Research Laboratory at the Dana‑Farber Cancer Institute.

Located in Boston and the surrounding communities, Dana‑Farber Cancer Institute is a leader in life‑changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high‑risk and underserved populations.

We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School‑affiliated hospitals.

Our research group investigates the biology and risk factors associated with pancreatic and other gastrointestinal cancers. We aim to improve outcomes for patients with these diseases both by identifying cancer earlier, when the chance for a cure is greater, and by improving therapy. We focus on learning from cancer patients by studying human biospecimens so that our discoveries can be rapidly and confidently translated into improved clinical care.

Our laboratory members include epidemiologists, biostatisticians, pathologists, data scientists, molecular biologists, and clinical researchers, all of whom contribute their unique expertise to our lab’s work. We employ a broad variety of analysis approaches and techniques in our laboratory, including population‑scale epidemiology studies, digital pathology, genomic sequencing, and spatial transcriptomic and protein profiling. Our tissue profiling work encompasses both clinical trial correlative studies and landscape‑directed discovery studies.

We work closely with the Gastrointestinal Cancer Center Biobank to acquire blood, tissue, and other sample types from patients at Dana‑Farber Cancer Institute. Finally, we routinely collaborate both with investigators at Dana‑Farber and across the nation to study pancreatic cancer using model systems and to conduct and lead clinical trials.

• Design and conduct studies using multiplex immunofluorescence, spatial transcriptional profiling, and other cutting‑edge, high‑dimension tissue analysis approaches to evaluate pancreatic cancer pathology using human tissue specimens
• Collaborate with other laboratory members with expertise in pathology, molecular biology, and epidemiology/biostatistics
• Mentor and supervise research technicians performing tissue‑based analyses
• Serve as a liaison for collaborations with other laboratories and institutions
• Maintain laboratory protocol databases, patient tissue and slide archives, and digital assets
• Oversee and maintain laboratory infrastructure
• Assist in training new postdoctoral fellows and research technicians
• Conduct analyses using digital image processing software, such as inForm and QuPath, and statistical packages such as R and SAS
• Participate in group meetings and work collaboratively on larger projects with other group members
• Generate data for figures and tables to serve as the basis for published manuscripts
• Contribute to manuscripts describing research results
• Contribute to progress reports related to research funding

• Strong background in human pathology
• Experience with traditional pathology laboratory techniques, including slide sectioning, H&E staining, immunohistochemistry and special stains a plus
• Experience with translational pathology techniques, including multiplexed immunofluorescence, spatial transcriptomics, and RNA in situ hybridization a plus
• Experience in oncology research would be an advantage
• Strong commitment to cancer research is required
• Experience managing laboratory staff would be an advantage
• A…