Research Associate – Proteomics/Drug Target Validation Job Boston area,Massachusetts USA,Research/Development

Research Associate – Proteomics/Drug Target Validation

Monte Rosa Therapeutics is seeking to recruit a highly motivated research associate to join its Proteomics group in Boston to support hit confirmation and drug target validation. This is an exciting opportunity to join a team responsible for identification and validation of novel molecular glue degrader targets. The lab-based position will focus on developing and running cell‑based assays to validate hits from the company’s proteomics‑based screening platform.

The candidate should exhibit excellent communication and collaborative skills for working on cross‑functional multi‑disciplinary drug discovery teams.

Support research efforts discovering and validating small molecule screening hits through development of cellular assays, including target engagement, ternary complex, and degradation assays

Collaborate with team members to design and execute experiments using routine molecular biology, biochemistry, and cell culture techniques, including working with both immortalized and primary cell lines

Optimization and fine‑tuning of critical assay parameters such as optimal gene expression levels, seeding density, timeframe or co‑treatments

Compile and analyze experimental data and communicate research findings at internal meetings

Prepare and manage laboratory stocks of routinely used reagents

Accurately document experimental details through timely maintenance of electronic lab notebook records and the development of standard operating procedures (SOPs) for new protocols

BSc and/or MSc in Cell Biology, Biochemistry, or a related field, with at least 2 years of relevant industry or academic research experience

Proficiency in culturing mammalian cells and utilizing sterile techniques (ideally BSL2 standards)

Hands‑on experience with a variety of cell culture and cellular biochemistry techniques, including at least several of the following: transfection, lentiviral transduction, cell line generation, cell viability assays, SDS‑PAGE/Western blot, immunoprecipitation/co‑IP, and flow cytometry

Experience with cellular PPI, target engagement, ternary complex or degradation assays is preferred

Critical and independent thinking, strong analytical and problem‑solving skills

Highly collaborative and able to work in a matrix, interactive, and fast‑paced drug discovery environment.

Excellent oral and written communication skills to work in a collaborative, matrix team

Seniority level

Entry level

Employment type

Full‑time

Job function

Research, Analyst, and Information Technology

#J-18808-Ljbffr


Increase/decrease your Search Radius (miles)



Job Posting Language

Research Associate – Proteomics​/Drug Target Validation

Research Associate – Proteomics/Drug Target Validation