Senior​/Principal Research Associate, LNP Discovery​/PD

Company Description

About Mote Therapeutics:

Are you a scientific leader with a passion for advancing RNA therapeutics and the drive to make a difference in the world? Do you want to be a part of a dynamic and innovative team at the forefront of RNA medicines? If so, join our new RNA Venture and be a part of the revolution in RNA therapeutics!

Backed by Fapon Biotech, an international leader in in vitro diagnostics, biologics, and precision medicines, Mote Therapeutics is an innovative Lexington-based biotechnology startup building the RNA medicines of tomorrow. Led by a pioneer in the field of RNA therapeutics and supported by Fapon's Greater Boston R&D Center of Excellence, we're pulling together a team of talented scientists, leaders, and operations specialists to solve some of the major barriers to success that RNA therapeutics face.

About Fapon Biotech:

Founded in 2001 and headquartered in Guangdong, China, Fapon Group is mainly engaged in product R&D and services of in vitro diagnostics (IVD), biological therapies, and precision diagnostics and treatments. With our core value of "foresee and prepare for what the future demands", Fapon has historically focused on three major businesses: raw material solutions, IVD ecosystem platform service, and intelligent digital diagnosis and treatment.

Fapon's recent expansion into therapeutics was recently marked by success with the receipt of IND approval from the FDA for a differentiated CD47 antibody drug, the first in a rapidly expanding therapeutics effort.

With a global footprint, Fapon has established major production and sales (R&D) bases in Beijing, Shenzhen, Shanghai, the United States, Germany, India and other locations throughout the world, forming a global R&D, production, marketing, and service network with products being widely sold in 61 countries and regions.

You can learn more about us by visiting

An equal-opportunity employer, Fapon welcomes and encourages diversity in our workforce.

Job Description

Key Responsibilities:

We are seeking a scientific contributor to lead and execute novel LNP formulation process development activity for the delivery of circular RNA therapeutic s role will spearhead LNP process development/scale up activity and would be responsible for designing and executing DOE-based formulation process optimization. They would engineer and functionalize LNPs, develop analytics for formulation quality control, and develop processes to improve formulation  candidate would have the opportunity to work in a collaboration-oriented role in which they would coordinate with other teams, plan and run animal studies with a cross-functional group of scientists, and support the growth and career development of junior scientists.

The ideal candidate is a chemical engineer/pharmaceutical major with strong LNP formulation, optimization, and process development experience, who is excited by the idea of being a core participant in building an early startup and guiding the scientific vision of the company. They would be engaged in science and driven by our mission to create therapies that help people in ways that are currently impossible.

• Establish, execute and document protocols for preparation and characterization of targeted LNP formulations with nucleic acid cargo for in vitro and in vivo studies
• Design and execute DOE-driven studies for LNP composition, mixing parameters and process optimization to improve formulation quality, stability, delivery efficiency and functional activity
• Develop cell and molecular biology assays to assess the delivery efficiency of RNA cargo in mammalian primary cells to facilitate development of therapeutics drugs pipelines
• Assist in the buildout of formulation and analytical capabilities with focus on delivery with nanoparticle technology, lyophilization and process development for scale up/production
• Contribute to patent applications related to the delivery technology
• Support technology transfer to CDMOs and Industry Partners
• Foster collaborative relationships across the team and company and engage in a positive and exciting work environment
• Contribute to hiring, training, and collaborating with scientists (as needed) to formulate, characterize, develop, and support assessment of efficacy
• Plan and coordinate animal studies with in vivo team
• Author technical documents, including SOPs for formulation processes and analytical methods, maintain diligent records and demonstrate proficiency in scientific communication
• Support high-quality documentations to support regulatory filings

Qualifications

Minimum Qualifications:

• BS/MS in chemical engineering, chemistry, pharmaceutical sciences, or related field, preferably with industry experience of 2-5 years for MS or 5-8 years for BS candidates.
• Strong track record of productivity in nanoparticle research with an understanding of key challenges in nanoparticle/formulation scale-up and translation
• Prior experience in developing lyophilization protocols for nanoparticle formulation, and stability…