Principal Scientist/Senior Principal Scientist
Listed on 2026-01-13
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Research/Development
Research Scientist, Immunology Research, Clinical Research, Drug Discovery
Job Title
Principal Scientist/Senior Principal Scientist
FieldImmunology and Inflammation
CompanyHarbour Bio Med
LocationNewton/Boston, MA, USA
Company DescriptionHarbour Bio Med is a biopharmaceutical company headquartered in Shanghai with business operations and research centers in Boston and Netherlands. Harbour Bio Med leverages its proprietary transgenic mice to develop innovative, therapeutic, and fully human monoclonal antibodies against diseases with unmet medical needs.
Key ResponsibilitiesLead immunology discovery projects and champion projects from discovery into early clinical development. Develop and execute efficient strategies for target identification, prioritization and validation; review, propose, initiate, and implement new pre-clinical therapeutic antibody drug discovery and development programs in the field of Immunology and Inflammation. Represent in-house expertise in one or more areas of T cells, macrophages/DC, NK cells, ILC, or B cells.
Collaborate with CRO and academic partners; employ cutting-edge in vitro and in vivo animal and human models to advance drug discovery and development programs up to and including IND filing. Collaborate with clinical and business units to support clinical studies. Lead project team meetings, and present updates to senior management. Facilitate the writing of patents and regulatory documents. Present non-proprietary results on scientific conferences and publish in peer reviewed journals.
Qualifications
- PhD in immunology or related discipline
- 2-4 years of postdoctoral experience in immunology or related field
- More than 5 years of industrial experience, ideally in the field of immunology
- Demonstrated track record of independent critical thinking and scientific achievement in research, exemplified by strong publications in leading journals
- Experience of leading a drug discovery project in biopharmaceutical companies
- Expertise of in vitro primary immune cell based functional assays
- Extensive experience in flow cytometry, as well as molecular and cellular biology
- Knowledge and/or skills of in vivo models of immuno-inflammatory diseases
- Understanding of fundamentals and practice of antibody discovery, engineering, and development
- Excellent written and oral communication skills, as well as people organizational skill
- Enthusiasm in laboratory experimentation
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