Associate Scientist – In Vivo Preclinical Pharmacology

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve.

This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us. At the Lilly Innovation Center in Boston, Massachusetts, we explore how next generation therapeutics, new technologies, data analytics and new care models can improve patient health and the healthcare system.

Our Genetic Medicine team in Boston shares a passion for challenging conventional wisdom and creating an environment that embraces creative, break-through concepts. The Center offers a start-up environment with large company support. It is located in the heart of Massachusetts’ exploding science and technology cluster and is within walking distance of some of the best academic and industry innovators in the world.

• Work with project team leads to design and plan in vivo experiments to support the preclinical characterization and evaluation of novel therapeutic molecules.
• Perform rodent handling and dosing, including but not limited to subcutaneous (SC), intravenous (IV), intraperitoneal (IP) and intrathecal (IT) injections.
• Perform small animal stereotaxic surgeries including but not limited to intracerebral (IC), intracisterna magna (ICM) and intracerebroventricular (ICV) injections in rodents.
• Perform tissue dissection, trimming and processing, collect bodily fluids (blood, cerebrospinal fluid).
• Process tissue samples for gene expression or protein endpoints (e.g RT-qPCR, Western blot, ELISA)
• Support technology development for improving the delivery of novel therapeutics to regions of interest in the central nervous system or other tissues.
• Assist in troubleshooting technical challenges and provide scientific and technical input to project teams
• Help design and complete experiments and perform data analysis
• Provide written and verbal communication of work in lab reports and team meetings
• Accurate recording of all practical work: completion of electronic notebook to Lilly procedure quality standards
• General laboratory assistance, including ordering and receiving lab supplies, preparation of reagents, and maintain laboratory equipment
• Ensure compliance with all health and safety regulations
• Passionate about contributing in the lab in a diverse and inclusive environment every day

B.S. in biology, biochemistry, pharmacology or related scientific discipline 1+ years of experience working in the pharmaceutical industry, an academic laboratory, or similar settings Qualified applicants must be authorized to work in the United States on a full-time basis.

Experience in developing and working with in vivo models and assays to support drug discovery programs. Hands-on competencies in designing and delivering in vivo pharmacological experiments. Knowledge and understanding of drug delivery concepts is preferred. Strong expertise with in vivo tissue dissection and processing. Experience in gene expression assays (e.g. RT-qPCR) or protein assays (e.g. Western blot or ELISA) Ability to adapt and exercise flexibility for changing platform needs, workflows and projects.

Excellent communication skills and efficiency in collaborating across functional boundaries and in team environment Strong…