Director, Head of DNA-Encoded Library; DEL

Position: Director, Head of DNA-Encoded Library (DEL)
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Job Description The Head of DNA-Encoded Library (DEL) will provide scientific and strategic leadership for the development and application of DNA-encoded library technologies to accelerate small-molecule discovery. This leader will create Takeda’s DEL strategy and build a team to enable DEL screening in house. They will lead the design and build of DEL libraries, oversee DEL selections and data analysis, and guide cross-functional teams from hit identification through hit-to-lead progression.

The successful candidate will bring deep expertise in on-DNA chemistry, DEL platform development, and collaborative drug discovery, with a demonstrated ability to translate DEL-derived insights into high-quality chemical matter and actionable project decisions.

Key Responsibilities Define and implement internal and external DEL screening strategies aligned with discovery program objectives.

Build a team to fully execute DEL in house d the design, synthesis/acquisition, characterization, and quality assessment of DEL libraries.

Oversee DEL selection campaigns, including target preparation, assay design, controls, and experimental execution.

Direct DEL data processing, quality control, statistical analysis, and interpretation.

Evaluate DEL hits and establish prioritization strategies based on potency, selectivity, enrichment, chemical tractability, and develop ability.

Lead or coordinate hit identification, hit validation, resynthesis, and confirmation activities.

Partners with medicinal chemistry, biology, biophysics, structural biology, computational chemistry, DMPK, and project leadership teams to advance DEL-derived hits through hit-to-lead.

Provide scientific guidance on on-DNA reaction development, DNA-compatible chemistry, building-block selection, and library design.

Establish platform capabilities, workflows, standards, and best practices for DEL screening and data analysis.

Present scientific strategy, results, risks, and recommendations to senior leadership and project teams.

Build external collaborations and maintain awareness of emerging DEL technologies, methods, and competitive advances.

Mentor and develop scientists while fostering a collaborative, innovative, and scientifically rigorous culture.

Leadership Competencies Strategic and innovative scientific thinker

Collaborative and inclusive team leader

Strong cross-functional influencer

Results-oriented and accountable

Skilled at translating complex data into clear decisions

Effective mentor and people developer

Comfortable operating in a fast-paced, matrixed environment

Qualifications (Required)
Expected Requirements:

PhD in Chemistry, Medicinal Chemistry, Chemical Biology, Biochmistry or a related scientific discipline with 10+ years of relevant industry experience in drug discovery, DEL technology, or a closely related field; orMS in a relevant scientific discipline with 16+ years of relevant experience.

Demonstrated expertise in:

DEL library design and synthesis

On-DNA chemistry and DNA-compatible reaction developmentDEL selection design and executionDEL data analysis and hit triage

Hit identification, validation, and hit-to-lead activities

Proven ability to define and execute DEL strategies across multiple discovery programs.

Experience leading cross-functional teams in a matrixed research environment.

Strong record of scientific innovation, collaboration, and delivery of high-quality discovery outcomes.

Excellent…