Senior Scientist, -Throughput Chemistry

About Us:

Jnana Therapeutics, a wholly owned subsidiary of Otsuka Pharmaceutical, is a clinical-stage biotechnology company leveraging its next-generation RAPID chemoproteomics platform to discover medicines for highly validated, challenging-to-drug targets to treat diseases with high unmet needs. Jnana is focused on developing first- and best-in-class therapies to treat a wide range of diseases, including rare diseases and immune-mediated diseases. Jnana’s lead program, JNT-517, which targets an allosteric site on the phenylalanine transporter SLC6A19, is a potential first-in-class oral approach for the treatment of PKU, a rare genetic metabolic disease.

Located in Boston, Jnana brings together scientific leaders in small molecule drug discovery and development, and a highly experienced management team. For more information, please visit  and follow us on Twitter/X and Linked In.

At Jnana, you’ll join a diverse, passionate team dedicated to advancing therapies for challenging diseases. Our collaborative, purpose-driven culture fosters innovation, urgency, and belonging—making Jnana a great place to work!

As a Scientist in our Discovery Chemistry group, you will support our internal chemistry group focused on drug discovery programs for hard-to-drug targets. Through small molecule screening using our novel and proprietary chemoproteomics RAPID platform, our research aims to identify novel small molecules against these challenging targets to interrogate target biology and ultimately to develop drug candidates that can provide clinical value to patients.

• Execute direct-to-biology, high-throughput chemistry to support the platform
• Develop and optimize new reactions for direct-to-biology chemistry
• Contribute to establishment of the high-throughput chemistry function and planning/build out of laboratory automation
• Utilize synthetic expertise to design and execute synthesis of target molecules
• Work closely with external chemistry CRO teams to synthesize target molecules
• Work collaboratively across scientific disciplines on multiple projects
• Proactively engage in brainstorming and the generation of new ideas across projects
• Assist in preparing patent applications and publications
• Maintain a safe and productive laboratory environment

• Ph.D. in Medicinal Chemistry, Organic Chemistry, or closely related field with at least 3 years industry experience in parallel synthesis, liquid handling, high-throughput experimentation and/or direct-to-biology chemistry
• Passion for drug discovery, highly-organized and excellent communication skills

• Accountability for Results
  - Stay focused on key strategic objectives, be accountable for high standards of performance, and take an active role in leading change.
• Strategic Thinking & Problem Solving
  - Make decisions considering the long-term impact to customers, patients, employees, and the business.
• Patient & Customer Centricity
  - Maintain an ongoing focus on the needs of our customers and/or key stakeholders.
• Impactful Communication
  - Communicate with logic, clarity, and respect. Influence at all levels to achieve the best results for Otsuka.
• Respectful Collaboration
  - Seek and value others’ perspectives and strive for diverse partnerships to enhance work toward common goals.
• Empowered Development
  - Play an active role in professional development as a business imperative.

This job description is intended to describe the general nature and level of the work being performed by the people assigned to this position. It is not intended to include every job duty and responsibility specific to the position. Otsuka reserves the right to amend and change responsibilities to meet business and…