Scientist, SPR

We are a seed stage biotech company focused on discovering modulators of the RNA lifecycle for undrugged disease drivers. We seek a creative and motivated Scientist with industry experience and a background in biophysical and biochemical assay development for novel small molecule discovery
. You will report to the Director of Biochemistry and work closely with a small, collaborative team at our site in Cambridge, Massachusetts.

This role is hands-on and lab-focused
, requiring independent development and execution of rigorous biophysical and biochemical experiments within an early-stage biotech environment. The successful candidate will combine strong experimental skills with the ability to communicate clearly and collaborate with scientists across multiple disciplines.

We were founded by academic leaders in RNA biology and are financed by The Column Group.

• Ownership of SPR
  : establish workflows, generate data, maintain our instrument, troubleshoot, manage external SPR efforts, and communicate progress and direction.
• Propose, evaluate, and establish additional biophysical and biochemical assays, approaches, and technologies to advance RNA-targeting discovery efforts.
• Document and maintain high-quality SOPs, including timely electronic lab notebook entries.
• Oversee CRO partners across assay design, execution, and troubleshooting.

• MS + 4 years experience or PhD in Biophysics, Biochemistry, Biology, Chemistry, or other relevant field
• 2-4 years of industry experience in small-molecule drug discovery (biotech or pharma).
• Hands-on expertise with a diverse set of biophysical methodologies for interrogating interactions between RNA and small molecules (e.g., SPR, BLI, TR-FRET).
• Experience translating mechanistic and structural insights into practical strategies for optimizing and advancing hits to leads.
• Proven ability to work independently and drive projects with minimal supervision
• Excellent communication skills and collaborative mindset
• Authorized to work in US

• Experience in early-stage biotech environment(s)
• Track record of publications or patents in small-molecule drug discovery

• Collaborative, science-driven culture
• Direct impact on project strategy and company direction