Co-Op , Long Read Sequencing

Kickstart Your Career at Vertex!
Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co‑op,you’llwork on meaningful projects, collaborate with talented teams, and learn from industry leaders.

We’repassionate about innovation, inclusion, and supporting your growth—inside and outside the lab.

Why Vertex?

• Real Projects:You’llwork on assignments that make a real impact, not just busy work.

• Mentorship & Networking:Connect with leaders and peers who want to see you succeed through professional networks, connections, and collaborations that will shape your longer‑term career.

• Flexible & Supportive:We offer flexible work options with Flex @ Vertex and prioritize your wellbeing.

• Inclusive Culture:Collaboration and inclusion are embedded in everything we do.

• Career Launchpad:Build skills, explore career paths, and get guidance for your future career.

Your Impact

The Vertex Long Read Sequencing Co‑Op is a 6‑month experiential training program for students currently working towards an advanced degree in Biological Sciences, or other related fields. If you are passionate, collaborative, and growth‑minded, a co‑op at Vertex will help you gain meaningful experience in our BSMO CGT AD functional areas and serve as a launchpad for your career.

The Final date to receive applications for this co‑op is November 15th. Please note that Vertex reviews applications on a rolling basis and reserves the right to close this job posting prior to the listed deadline. Applicants can expect to receive an update about their application before or shortly after the Final date to receive applications.

Ready to apply? Submit your application andlet’sturn possibilities into reality!

What you will be doing:
The long sequencing project will cover various applications listed below:

• RNA Sequencing for modification (m6a, m5c, pseudouridine, etc.) and isoform analysis to characterize stem cells and stem cell derived pancreatic islets.

• Conduct plasmid integration analysis for development and assessment of monoclonal antibody-producing cell lines, using targeted or whole genome sequencing.

• Direct RNA or cDNA sequencing to verify monoclonal antibody heavy‑and light‑chain sequences and support variant calling.

• Evaluate mRNA integrity and polyA tail characterization using direct RNA sequencing.

Required Skills:

• Nucleic acid extraction, cDNA preparation and sequencing library preparation

• Ability to design and analyze experiments for developing analytical assay

• Experience with Oxford Nanopore systems

• Proficiency with R or Python, Linux system and high process computing system

• Familiarity with bioinformatics tools such as minimap2 and samtools

• Data analysis tools such as DESEQ2 and Gene Set Enrichment Analysis

Key Deliverables at Project Completion:

• Establish workflows/assay to support applications of long read sequencing

• Execution of the experiments and analyzing the dataset with statistical approach

Key Learnings Expected:

• Knowledge pertaining to developing an assay and bringing it through feasibility assessment such as accuracy and precision.

• Deeper understanding into principles of stem cell and pancreatic islets biology

• Presentation of large dataset and experimental findings.

Qualifications:

• Master's / PhD

• Majors:
  Systems Biology, Computational Biology, Developmental Biology, Stem Cell Biology, Biochemistry, Biological Engineering, etc.

• Legal authorization to work in the United States, now and in the future. Please note that Vertex does not provide sponsorship for internships/co-ops or entry level roles…