Director, Clinical Sciences

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

Tango is located at 201 Brookline Avenue, in the vibrant Fenway area of Boston, Massachusetts.

Tango has an exciting opportunity to join the team as our Director, Clinical Sciences. This is a hands‑on role with scientific contributions to one or more clinical development programs. The successful candidate will actively engage in the design, execution, analysis, and interpretation of clinical studies. You will ensure scientific rigor throughout study conduct, lead data review and analysis, and partner cross‑functionally to advance clinical development programs.

This role reports to the Executive Director, Clinical Sciences.

• Scientific contribution to one or more clinical programs to ensure the successful design, execution, and interpretation of clinical studies
• Provide scientific leadership throughout the design, execution, analysis, and interpretation of early- and late-stage oncology clinical trials
• Partner closely with Clinical Development physicians, Clinical Operations, Biostatistics, Clinical Pharmacology, Pharmacovigilance, Regulatory Affairs, Translational Medicine, and Medical Writing to ensure high-quality execution of clinical programs
• Contribute to the development and review of key clinical documents, including protocols, investigator brochures, informed consent forms, clinical study reports, clinical development plans, and regulatory briefing materials
• Interpret emerging clinical, safety, PK/PD, and biomarker data to inform study conduct, dose selection, expansion opportunities, and overall development strategy
• Contribute scientific expertise to regulatory submissions and health authority interactions
• Foster a collaborative, accountable, and scientifically rigorous culture within the Clinical Science function
• Perform additional duties and responsibilities as required

• MD, PhD, PharmD, MS within a relevant scientific discipline
• At least 10 years of experience in clinical science, or research
• At least 5 years of experience in oncology
• Demonstrated experience in designing and managing clinical trials, including knowledge of regulatory guidelines and GCP
• Strong analytical skills with proficiency in statistical analysis and interpretation of clinical data
• Excellent written and oral communication skills, with the ability to convey complex scientific concepts to diverse audiences
• Experience working in a fast‑paced environment

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Salary range

$190,400 - $285,600 USD

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Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in aconfidential file.

As set forth in Tango Therapeutics’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law.

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