Research Technician – Transplant Immunology and Cellular Therapy

A full-time position is available for a highly motivated research technician to join a growing translational immunology team studying how donor T cells distinguish leukemia from healthy tissues after allogeneic hematopoietic cell transplantation (allo-HCT). Our research aims to decode the molecular basis of alloreactivity — one of the central unsolved problems in transplantation immunology — and to translate these discoveries into next-generation personalized immunotherapies, including engineered CAR T-cell approaches to prevent relapse while minimizing graft-versus-host disease (GvHD).

The laboratory combines cellular immunology, genomics, immunopeptidomics, gene engineering, induced pluripotent stem cells (iPSCs), and single-cell technologies to identify the antigens recognized by alloreactive T cells and develop novel CAR-based cellular therapies. The technician will work closely with senior scientists and collaborators across Dana-Farber Cancer Institute, Boston Children’s Hospital, Harvard Medical School, and the Broad Institute.

Projects may include processing human clinical samples, performing immune assays, cloning T-cell receptors, engineering T cells, and testing novel immunotherapies in preclinical models. The position offers extensive training in cutting-edge experimental approaches and significant opportunities for scientific growth, presentations, and co-authorship on publications. Training is available in all protocols and procedures; prior experience with basic techniques in cell culture and molecular biology is strongly preferred.

As a growing research program, the laboratory offers a highly interactive and mentorship-focused environment where motivated trainees can take on substantial scientific responsibility and gain broad exposure to experimental design, data analysis, and collaborative translational research. Successful candidates will have the opportunity to make meaningful intellectual contributions to projects and participate closely in the development of a young and dynamic research team.

We are a highly collaborative and interdisciplinary team that values scientific curiosity, rigor, creativity, and mentorship. The ideal candidate will be excited to work at the interface of immunology, genomics, and translational medicine in a fast-paced and supportive research environment.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life-changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds and design programs to promote public health, particularly among high-risk and underserved populations.

We conduct groundbreaking research that advances treatment, educate tomorrow’s physician-scientists, and work with outstanding partners across the Harvard medical community.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations.

We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

The candidate will independently…