Principal Scientist, Discovery Process Chemistry; DPC)

Our Company is currently seeking an exceptional scientific leader for our Discovery Process Chemistry (DPC) group at our Boston, MA site. The core responsibility of the successful candidate will be to lead a team of scientists in the development of innovative solutions to complex chemistry problems across a diverse portfolio of projects and modalities in the discovery phase, from lead identification through candidate selection, with the goal to apply these solutions to facilitate medicinal chemistry research by overcoming synthetic bottlenecks, streamlining SAR analogue synthesis, and providing access to novel chemical space.

The position is also responsible for defining scalable synthetic routes and successfully transitioning candidate compounds from discovery into early development, as well as managing supply of Active Pharmaceutical Ingredients (APIs) at varying scales during this period. Close collaboration with chemistry colleagues in Medicinal Chemistry and Process Chemistry, as well as a broad array of other discovery and preclinical research groups, will be expected.

As such, subject matter expertise in Medicinal or Process Chemistry is critical. The candidate must be highly self-motivated, demonstrate strong leadership, possess strong experimental skills, have excellent written and oral communication abilities, collaborate effectively on multidisciplinary teams, and be able to demonstrate flexibility in adapting to change in a fast-paced, dynamic research environment. In addition to supervising direct scientific reports, the candidate is also expected to provide broader mentorship and expertise across the DPC group.

The candidate will be expected to remain current with the latest synthetic methodologies, drive innovation, actively apply new concepts to continuously improve PR&D capabilities and expertise, and be active in the external scientific community via publications and external presentations.

Education Requirement:
PhD in Organic Chemistry

Required

Experience and Skills:

• A minimum of 5 years experience with a proven track record of scientific excellence and successful research
• Expertise in organic synthesis
• Demonstrated creativity and innovation in problem solving
• Productivity and efficiency working in the lab
• Proven track record of successful research in medicinal and/or process chemistry
• Strong written and oral communication skills
• Excellent collaboration skills
• Ability to contribute to and lead cross‑functional teams and influence team strategy and decision‑making
• Established scientific reputation supported by publications and external presentations
• Demonstrated ability to develop talent

Required Skills:

• Bioconjugation
• Clinical Chemistry
• Computational Chemistry
• High-Throughput Experimentation (HTE)
• Inorganic Synthesis
• Medicinal Chemistry
• Organic Chemistry
• Organic Synthesis
• Organometallic Chemistry
• Preclinical Research
• Process Chemistry
• Scientific Publishing
• Structure Based Drug Design
• Synthetic Chemistry

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.

As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.

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