Senior Director, Brand Lead - Varegacestat

Senior Director, Brand Lead – Varegacestat

Bothell, Washington, United States

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting‑edge targeted cancer therapies, including antibody‑drug conjugate therapies (ADCs). Our most advanced pipeline programs are varegacestat (formerly AL102), a gamma secretase inhibitor currently in a Phase 3 trial for treatment of desmoid tumors;

IM‑1021, a ROR1‑targeted ADC currently in a Phase 1 trial; and IM‑3050, a FAP‑targeted radioligand, which recently received IND clearance. Our pipeline also includes IM‑1617, IM‑1335, and IM‑1340, all of which are preclinical ADCs pursuing undisclosed targets with expression in multiple solid tumors.

The Senior Director, Brand Lead for Varegacestat offers an exceptional opportunity for an experienced, strategic, and scientifically grounded leader with a proven record in launching novel oncology therapies. Varegacestat is a potential best‑in‑class agent under investigation for desmoid tumors. This role will lead the U.S. launch efforts across both healthcare provider (HCP) and patient channels and drive overall cross‑functional launch readiness.

The position requires advanced expertise in pharmacology and clinical therapeutics to drive HCP education, shape the brand’s scientific narrative, and ensure effective communication of Varegacestat’s clinical value. As a key member of the leadership team, this individual will define and execute the marketing strategy for the brand, playing a pivotal role in advancing Immunome’s oncology portfolio and setting the foundation for long‑term growth.

• Lead the development of brand strategy and scientific narrative grounded in clinical differentiation and pharmacologic profile from the RINGSIDE study (the pivotal registration phase III trial).
• Shape brand positioning by integrating clinical data, mechanistic insights, and competitive intelligence to highlight therapeutic value and differentiation.
• Design and implement engagement strategies with key academic and community institutions, key opinion leaders, and key healthcare providers to ensure scientific alignment and clinical awareness.
• Lead the creation of annual brand strategic and tactical plan.

• Lead the design and execution of medical and promotional education for HCP audiences that effectively communicate Varegacestat’s clinical profile (mechanism of action, dosing, efficacy and safety profile).
• Manage marketing mix investments across all commercial verticals, ensuring data‑driven decisions that reinforce awareness and scientific credibility.
• Enhance Immunome’s visibility and reputation by amplifying presence at major oncology congresses.
• Collaborate with medical affairs, clinical development, legal and regulatory teams to ensure all communications to healthcare professionals and patients are scientifically accurate, therapeutically appropriate, and uphold FDA OPDP regulations.

• Lead the selection and management of creative and media agency partners to support timely and best‑in‑class launch.
• Support the development of efficient commercial MLR process and Veeva Valut execution.
• Represent the commercial function in cross‑functional governances to drive program‑level decisions.
• Partner with finance and commercial analytics functions to ensure plans maximize brand value and provide regular updates to senior leaders on promotional strategies, tactics, and overall brand performance.
• Support executive leadership through strategic insights, ad‑hoc analyses, and data‑driven recommendations to maximize brand and organizational impact.

• A minimum of 10 years of experience in U.S. and Global marketing in the pharmaceutical or biotech industry with demonstrated expertise in pharmaceutical brand strategy or…