Synthetic Chemist

Boulder, CO.Platform – Differential Platform /Full-time /On-site

Let’s build the future of medicine - together.

Boulder, CO | Full-Time | $125,000–$135,000

YOUR ROLEAs a Synthetic Chemist (Scientist I) at Enveda, you'll build Enveda's library of synthetic authentic standards: human metabolites made quickly and at scale, so our mass spec platform can confirm what it finds. You'll partner with analytical chemists, data scientists, and our Sample Management and Lab Automation teams to turn computationally predicted structures into confirmed compounds. In your first year, you'll stand up our high-throughput synthesis workflow and deliver 250,000 confirmed authentic standards across multiple compound classes.

This is a high impact opportunity where you'll influence our mass spec platform and Enveda's compound collection strategy while collaborating with some of the brightest minds in the industry.

WHAT YOU'LL DOOwn and design syntheses for our authentic standard library, from target list to confirmed compound, including efficient routes to structurally diverse natural metabolites and under explored compound classes, designed so each compound can be confidently confirmed by LC-MSDevelop and scale parallel or mixture synthesis workflows that enable rapid production of metabolite authentic standards for analytical validation

Build the infrastructure and processes to maximize compound production, partnering with our Sample Management and Lab Automation teams on high-throughput experimentation and automation

Translate computationally predicted molecular structures into confirmed, fully characterized compounds, closing the loop between data science and wet-lab chemistry, fast enough that synthesis is never the bottleneck

Establish best practices for synthesis prioritization, route scouting, and library design so the team can move quickly through large numbers of targets

Work in tight feedback loops with analytical chemists and data scientists who are predicting novel metabolite structures from mass spectrometry data at scale

Support the metabolomics teams who rely on synthetic standards to validate discoveries, and the drug discovery teams who build on the metabolites your standards help confirm

Help shape Enveda's compound collection strategy, deciding which regions of chemical space to explore next and how to build a library with lasting scientific valueWHAT WE'RE LOOKING FORA PhD in synthetic organic chemistry with 2+ years of hands-on experience in small molecule synthesis design, execution, and analysis

Someone energized by variety: comfortable pivoting between compound classes, adapting routes on the fly, and working across dozens of distinct scaffolds rather than a single total synthesis campaignA chemist who genuinely enjoys working at the boundary of computation and synthesis, and who sees data-driven target selection as an opportunity rather than a constraint

Hands-on experience running library, parallel, or high-throughput synthesis at the bench (you ran the plates, not only designed them), with a track record of delivering compounds on a timeline

Comfortable using LC-MS to interpret complex mixtures, not just to monitor reactions

Out-of-the-box thinking, the ability to envision and build capabilities, and the ability to work effectively within a multi-disciplinary team

Experience with high-throughput experimentation (HTE) and automation platforms is a plus Someone who enjoys challenging problems, thinking big, and stretching the bounds of what's possible

We hire for trajectory, not just credentials. If you meet most of the above and care deeply about this problem, we want to hear from you. ABOUT ENVEDAWe're a clinical-stage, AI-enabled biotech discovering medicines from nature four times faster…