ADME​/DMPK Technical Expert

Syngenta Crop Protection is a leader in agricultural innovation, bringing breakthrough technologies and solutions that enable farmers to grow healthy and nutritious food while taking care of the planet. We offer a leading portfolio of crop protection solutions for plant and soil health, as well as digital solutions that transform the decision-making capabilities of farmers. Our 17,900 employees serve to advance agriculture in more than 90 countries around the world.

Syngenta Crop Protection is headquartered in Basel, Switzerland, and is part of the Syngenta Group.

Our employees reflect the diversity of our customers, the markets where we operate and the communities which we serve. Regardless of your position, you will have a vital role in safely feeding an ever-increasing population while taking care of our planet. Join us and help shape the future of agriculture.

Are you a proactive problem solver with a passion for driving technical innovation? If so, we have good news as we are looking for an experienced DMPK/ADME Technical Expert to join our Analytical Metabolism and Methods (AMM) group within Product Safety. Within this role, you will make a key impact in projects by delivering innovative study designs to aid our understanding of the Absorption, Distribution, Metabolism and Excretion (ADME) and Pharmacokinetics (PK) and/or Toxicokinetics (TK) of chemicals in mammalian toxicology species.

You will work within a highly collaborative team of study managers and technical experts, while applying your scientific expertise to interpret complex DMPK/ADME data for project teams, directly supporting the development and registration of sustainable crop protection products. A recent example is the registration of TYMIRIUM® technology which protects crops against soil-borne pests. Additionally you will build effective partnerships with Contract Research Organisations (CROs), directing external study execution and collaborating to resolve technical challenges to secure the timely delivery of externally placed studies.

Key responsibilities will include:

• Overseeing CRO delivery:
  Ensuring the timely delivery of business critical data generated at CROs, while being responsible for study strategy documents, protocol design, evaluation of data and reviewing/authorising company reports.
• Delivering technical insights:
  Elucidating insights from ADME and PK/TK data and reporting expert conclusions to metabolism teams.
• Applying regulatory expertise:
  Utilising your expert knowledge and understanding of ADME, PK/TK as well as relevant global regulatory guidance documents and their implication to optimise and de-risk our study designs. Keeping abreast of changes to regulatory guidelines and requirements.
• Partnering with CROs:
  Independently providing technical guidance and problem-solving support to external suppliers, where appropriate, to facilitate transfer of technical knowledge.
• Driving continuous improvement:
  Leading or contributing to the creation and optimisation of new processes, technical guidance documents and report templates to improve efficiency and consistency across the team.
• Serving as a scientific contributor within the ADME, PK/TK expert area, providing expertise to metabolism teams and other functional areas as required.

What we are looking for

• Minimum of a degree or equivalent in a biology- or chemistry-related discipline.
• Significant knowledge in the areas of DMPK/ADME, with expertise in pharmacokinetics and/or toxicokinetics.
• Familiarity of global Regulatory Test Guidelines (e.g. OECD 417) relevant to ADME and toxicokinetics studies conducted to GLP standards for the registration of crop protection chemicals.
• Experience in translating complex datasets into key…