Scientist​/Sr Scientist - Discovery

The Principal Scientist, Discovery will facilitate the advancement of new ligands and technologies for Eli Lilly’s discovery oncology programs. This position will require development, optimization, and standardization of methods to characterize new ligands being investigated as potential radiopharmaceuticals. The ideal candidate will have technical experience with in vitro and cell-based assays, mammalian cell culture, fixed/live cell microscopy methods, and immunofluorescence. The Principal Scientist will work cross‑functionally with members of the discovery and preclinical team to execute research activities on site and with external partners.

• Independently perform biochemical and/or cell-based assays to characterize the activity of early‑stage ligands, such as fluorogenic reporter assays and co‑localization experiments via microscopy and immunofluorescence.
• Develop and optimize 2D and 3D cell lines as functional models for compound behaviour.
• Passage and prepare mammalian cells to be used in assays.
• Develop methods to assess compound affinity, retention, and internalization of compounds.
• Support the generation of in vitro assay data for established projects.
• Interface with external vendors to support early discovery activities.
• Critically assess data and methods, adapting and adjusting procedures as necessary.
• In conjunction with managers, establish priorities and meet timelines for key experiments.
• Provide clear communication of scientific data to co‑workers through internal presentations and written methods.
• Support preclinical and late‑stage assets as necessary.

• Ph.D. in chemistry, biochemistry, chemical biology, pharmacy, or related discipline or M.Sc in chemistry, biochemistry, chemical biology, pharmacy, or related discipline with 3‑5 years of industry experience.

• 3+ years relevant postgraduate experience (industry preferred).
• Demonstrated success independently designing experiments and planning scientific projects.
• Experience with biochemical assays using primary and immortalized cell lines.
• Strong background in the development and optimization of cell‑based reporter assays and cytotoxicity assays.
• Experience performing in vitro biochemical/biophysical assays and flow cytometry.
• Familiarity with confocal microscopy, immunofluorescence and imaging of live/fixed cells.
• Ability to communicate scientific data effectively to an interdisciplinary team.
• Excellent problem‑solving and decision‑making skills.
• Working knowledge of MS Office, Graphpad Prism, Flow Jo, and Chem Draw.
• Experience with radio binding assays or handling of radioactive materials is an asset.
• Experience with protein purification and analysis methods is an asset.

The position will be working onsite at a lab in Toronto, ON, with the anticipation of travel for team and client meetings.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $ – $.

Lilly does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability, or any other legally protected status.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.