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Senior Principal Engineer - Graph

Job in Brentford, Greater London, TW8, England, UK
Listing for: GlaxoSmithKline
Full Time position
Listed on 2026-06-04
Job specializations:
  • Software Development
    AI Engineer, Software Engineer, Data Engineer
Salary/Wage Range or Industry Benchmark: 100000 - 125000 GBP Yearly GBP 100000.00 125000.00 YEAR
Job Description & How to Apply Below

The primary purpose of this role is to take technical accountability for the CMC Knowledge Graph, driving forward its design and implementation through being hands‑on and by providing technical direction and oversight to the rest of the development team, while also working closely with Product Management, business representatives and other Tech & Data experts to ensure that it meets the business requirements.

More broadly, the role will additionally:

  • Support the CMC Knowledge System Director, product managers, business leaders and other stakeholders to identify opportunities where Knowledge Graph and other Data & AI capabilities can have a transformative impact on GSK’s CMC and New Product Introduction (NPI) processes
  • Provide technical leadership for other Data & AI Products in the CMC/NPI portfolio

The immediate priority in the role is to drive the technical work needed to product ionise an existing proof‑of‑concept CMC Knowledge Graph and its associated analytics use‑cases into a full‑fledged, sustainable, supportable Data & AI Product.

In this role you will…
  • Lead the ongoing technical design, development, testing and release of the CMC Knowledge Graph and other Data & AI solutions in the CMC/NPI portfolio
  • Provide leadership, technical guidance, and mentorship to the development team (both internal staff and contractors), driving performance and continuous improvement, including identifying and realising opportunities to increase velocity
  • Use hands‑on technical problem‑solving expertise to address technical challenges throughout the product life‑cycle
  • Support Product Management in creating and evolving a compelling product vision and roadmap, using expertise and insights on the art‑of‑the‑possible as well as engaging users and other business stakeholders to gather feedback and identify system enhancements
  • Collaborate with the Data & AI Architecture team and other stakeholders to ensure alignment with established architecture standards, contributing to and evolving them to incorporate new technologies and patterns as needed
  • Ensure compliance with relevant policies and procedures (including GxP validation where required)
  • Provide input to, review and approve key technical documents (e.g. design spec, validation plan)
  • Stay updated with the latest advancements in Knowledge Graph and related technologies, recommending and implementing improvements to enhance system functionality and performance
  • Lead discovery / proof‑of‑concept activities to establish early technical feasibility of new products or product features

Closing Date for Applications:
Tuesday 5th March 2024

Basic Qualifications/

Experience:
  • Strong technical expertise in designing, developing, and supporting Knowledge Graphs, including proficiency in working with RDF graph technologies, preferably Azno.
  • Proven track record in delivering complex data engineering projects in a cloud environment, preferably Azure.
  • Experience in leading and managing technical teams
  • Expertise in data modelling/ontologies, data integration, and data transformation techniques.
  • Strong programming skills and proficiency in utilising code repositories, such as Git, for efficient version control, collaboration, and code management.
  • Experience with Dev Ops principles and CI/CD practices to automate software delivery, streamline development processes, and ensure efficient deployment and monitoring
Preferred Qualifications /

Experience:
  • Understanding of pharmaceutical industry data and domain knowledge within CMC.
  • Knowledge of GxP compliance requirements and experience implementing them in data engineering projects

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to affirmative action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class (US only).

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities, contact us on Uk or .

We do not accept referrals from employment businesses or agencies for the vacancies posted on this site. All employment businesses/agencies are required to obtain prior written authorization from GSK before referring any candidates. In the absence of such authorization, any actions undertaken by the employment business/agencies shall be deemed to have been performed without the consent or contractual agreement of GSK.

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Position Requirements
10+ Years work experience
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