Director, Translational Medicine Expert; Neurodegeneration

Position: Director, Translational Medicine Expert (Neurodegeneration)
Salary Range:96,036.

Job Description Summary #LI-Hybrid Internal job title:
Director

Location:

London, UKThe Director, Translational Medicine Expert (Neurodegeneration) will lead the end to end translational strategy for neurodegenerative programs, bridging preclinical research to early clinical development (Phase 1–2).This role is accountable for biomarker strategy, clinical endpoint selection, and early phase trial design, enabling efficient, data driven decision-making through key development milestones (e.g., Transition Decision Points) and ensuring competitive differentiation of neuromuscular  addition, he/she oversees the planning, execution, and interpretation of clinical trials research, data collection activities and clinical operations.

Establishes and approves scientific methods for design and implementation of clinical protocols, data collection systems and final reports. Support new and ongoing clinical research and clinical trials and ensure efficient and timely processing of confidentiality agreements and clinical agreements

Job Description

Key Responsibilities:

1. Translational Strategy & Program Leadership Define and execute integrated translational strategies across neurodegeneration programs

Lead translational components from preclinical Phase 1/2 clinical studies

Drive program progression through key decision gates (e.g., IND, TDP, IDPA)
Ensure strong mechanistic linkage between target biology, biomarkers, and clinical endpoints
2. Biomarker & Endpoint Leadership Collaborate with Biomarker Development colleagues toward development and validation of:

Molecular biomarkers (tissue, blood, CSF where applicable)
Functional endpoints (strength, mobility, disease-specific measures)
Patient-reported outcomes (PROs)
Establishing quantitative biomarkers to support:

Target engagement

Disease modification

Dose selection and PoC decisions

Integrate biomarker strategy into clinical protocols and operational plans

Drive early biomarker de‑risking, a key priority in neuromuscular programs
3. Early Clinical Development (Phase 1/2)
Co‑lead design and execution of early clinical studies

Define:

Dose escalation strategy

Exposure–response framework

Translational endpoints (biopsy, imaging, functional)
Ensure TM leadership within Clinical Trial Teams (CTTs) for:

Trial design

Execution oversight

Data interpretation and decision-making
4. Cross-Functional Leadership Serve as core Translational Medicine representative within global project teams

Partner closely with:

Clinical Development Biomarker Development Clinical Pharmacology (PKS)
Preclinical Safety (PCS)
Regulatory Drive alignment between research, TM, and development organizations
5. External Scientific Leadership Build and lead collaborations with:

Academic KOLsPatient advocacy groups (critical in rare neuromuscular disease)
Technology partners (imaging, omics platforms)
Contribute to scientific strategy and external positioning of programs
6. Patient-Centered Development Integrate the patient voice into translational and clinical strategies

Advance:

Meaningful functional endpoints

Patient-relevant outcome measures

Innovative trial approaches (e.g., decentralized models where feasible)7. Portfolio Contribution & Strategic Input Contribute to:

Asset prioritization and portfolio strategy

Competitive differentiation strategy (e.g., vs RNA or gene therapy competitors)
Provide scientific input to:

Business development / due diligence

Indication expansion strategies

Essential Requirements:
· MD, neurologists, clinical training in neurodegenerative diseases
· Experience in translational medicine, early clinical development, or experimental therapeutics.
· Ability to shape development strategies, execute early clinical studies, and influence regulatory/packages supporting…