Senior Scientist, Stem Cell Model Engineering

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity‑related conditions.

As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award‑winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

In this vital role, you will join the Predictive Biology team as a hands‑on scientist focused on building genetically engineered human induced pluripotent stem cell (iPSC) models to support target discovery, target validation, and mechanism‑of‑action studies. You will troubleshoot complex systems, improve current workflows, and help drive the next wave of innovation in human stem cell model engineering.

• Develop genetically defined iPSC model systems, including reporter, tagged, loss‑of‑function, disease‑relevant, inducible, or otherwise perturb able models.
• Define and interpret fit‑for‑purpose validation strategies to determine whether engineered models are suitable for downstream biological studies.
• Identify, troubleshoot, and solve technical and biological failure modes, including poor editing outcomes, clonal artifacts, expression instability, differentiation defects, and loss of engineered function.
• Drive innovation by identifying technical gaps, improving workflows, and building new capabilities in engineered human stem cell models.
• Communicate technical risks, timelines, decision points, and model readiness clearly through written and oral presentations.
• Maintain high standards for data integrity, reproducibility, documentation, and experimental rigor.

We are all different, yet we all use our unique contributions to serve patients. The Senior Scientist we seek is a professional with these qualifications.

• PhD in a related discipline with 2+ years of experience.
• MSc with 5+ years of experience.
• BSc with 8+ years of experience.

• PhD with 2+ years of postdoctoral and/or industry experience in stem cell biology, molecular biology, cell engineering, genetics, developmental biology, bioengineering, or a related discipline.
• Demonstrated hands‑on experience generating CRISPR edited human iPSC models or other difficult‑to‑engineer human cellular model systems.
• Strong experimental judgment in genome‑engineering strategy, model design, validation requirements, and interpretation of engineered cell model data.
• Practical understanding of common failure modes in engineered iPSC models, including clonal artifacts, unintended genetic changes, expression instability, differentiation issues, and loss of engineered behavior.
• Demonstrated scientific productivity and technical credibility through peer‑reviewed publications and patents.
• Strong communication and collaboration skills and ability to work effectively as part of a multidisciplinary team.

As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well‑being.

The salary range for this position in Canada is $115,503 - $156,269 CAD. In addition to the base salary, Amgen offers competitive and comprehensive Total Rewards Plans that are aligned with local industry standards.

Apply now and make a lasting impact with the Amgen team.

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