Senior Scientist, Stem Cell Model Engineering

Sr. Scientist, Stem Cell Model Engineering

Join the Predictive Biology team as a hands‑on scientist focused on building genetically engineered human induced pluripotent stem cell (iPSC) models to support target discovery, target validation, and mechanism‑of‑action studies. You will troubleshoot complex systems, improve current workflows, and help drive the next wave of innovation in human stem cell model engineering.

• Develop genetically defined iPSC model systems, including reporter, tagged, loss‑of‑function, disease‑relevant, inducible, or otherwise perturbable models.
• Define and interpret fit‑for‑purpose validation strategies to determine whether engineered models are suitable for downstream biological studies.
• Identify, troubleshoot, and solve technical and biological failure modes, including poor editing outcomes, clonal artifacts, expression instability, differentiation defects, and loss of engineered function.
• Drive innovation by identifying technical gaps, improving workflows, and building new capabilities in engineered human stem cell models.
• Communicate technical risks, timelines, decision points, and model readiness clearly through written and oral presentations.
• Maintain high standards for data integrity, reproducibility, documentation, and experimental rigor.

• PhD in a related discipline with 2+ years of experience
• MSc with 5+ years of experience
• BSc with 8+ years of experience

• PhD with 2+ years of postdoctoral and/or industry experience in stem cell biology, molecular biology, cell engineering, genetics, developmental biology, bioengineering, or a related discipline.
• Demonstrated hands‑on experience generating CRISPR‑edited human iPSC models or other difficult‑to‑engineer human cellular model systems.
• Strong experimental judgment in genome‑engineering strategy, model design, validation requirements, and interpretation of engineered cell model data.
• Practical understanding of common failure modes in engineered iPSC models, including clonal artifacts, unintended genetic changes, expression instability, differentiation issues, and loss of engineered behavior.
• Demonstrated scientific productivity and technical credibility through peer‑reviewed publications and patents.
• Strong communication and collaboration skills and ability to work effectively as part of a multidisciplinary team.

The salary range for this position in Canada is $115,503 – $156,269 CAD. In addition to the base salary, Amgen offers competitive and comprehensive Total Rewards Plans that are aligned with local industry standards.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.