Senior Scientist - Target Discovery & Validation – Induced Proximity Platform; IPP

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas—Oncology, Inflammation, General Medicine, and Rare Disease—we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity‑related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives.

Our award‑winning culture is collaborative, innovative, and science‑based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Reports to:

Principal Scientist

Location:

Burnaby, BC

Let’s do this. Let’s change the world. Amgen is seeking a passionate and innovative Scientist to join the Induced Proximity Platform team in Burnaby. This role is at the frontier of discovery biology, combining induced proximity technologies to uncover novel therapeutic targets across Amgen’s key therapeutic areas including Oncology, Inflammation, and Cardiometabolic diseases.

The successful candidate will lead and support cell surface target discovery, validation, and functionalization efforts by developing and applying innovative in‑vitro assays, proteomics workflows, and flow cytometry‑based approaches. This role will contribute to large molecule multispecific therapeutic development through target validation, model development, and MOA studies, while collaborating across multidisciplinary teams to analyze data, communicate findings, and maintain high‑quality experimental documentation.

• Design, implement, and execute complex experimental workflows to profile and validate cell surface proteins.
• Lead and support cell surface‑based target discovery and validation projects using in‑vitro models (cell lines, primary cells, tissues, etc.).
• Apply proximity labeling, cell surface enrichment, and related proteomics efforts for target validation and nomination studies.
• Support target functionalization efforts toward developing multispecific antibody therapeutics, and perform efficacy, mechanism of action (MoA) and drug response studies for these therapeutics.
• Use cutting‑edge software tools and collaborate with bioinformatics to analyze and interpret target discovery proteomics datasets.
• Collaborate across multidisciplinary teams to drive integrated target discovery, validation and functionalization efforts.
• Present findings internally and externally through team meetings, conferences, and peer‑reviewed publications.
• Maintain detailed electronic lab notebooks and experimental records.

We are all different, yet we all use our unique contributions to serve patients. The qualified professional we seek is a Scientist with these qualifications.

• Doctorate degree and 3+ years of relevant scientific experience
• Master’s degree and 6+ years of relevant scientific experience

• Expertise in proximity labeling proteomics platforms and target validation using flow cytometry, biochemical and imaging‑based techniques.
• Experience in cell line generation and over-expression systems (e.g., lentiviral delivery).
• Experience with antibody therapeutics and functional validation of targets using cell‑based assays.
• Hands on experience with cloning, expression and purification analysis is a plus.
• Familiarity with high‑throughput automation platforms (e.g., Agilent Bravo), high‑content imaging platforms and analysis software.
• Track record of scientific innovation, publications, and/or conference presentations.
• Demonstrated ability to work collaboratively…