Senior Scientist, Stem Cell-Derived Tissue Models

Career Category

Scientific

Job Description

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission, to serve patients living with serious illnesses, drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions.

As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Let’s do this. Let’s change the world. In this vital role, you will join the Predictive Biology team to develop and validate biologically relevant models of human tissue using induced pluripotent stem cell (iPSC) or primary human tissue. A key focus will be validating tissue architecture, cellular composition, differentiation state, maturation, and functional relevance to ensure models are suitable for discovery and translational research.

• Develop human stem cell-derived models that represent tissue biology and enable disease-versus-normal comparisons.
• Differentiate stem cells into diverse tissue-relevant cell types.
• Build complex model systems, including organoids, assembloids, co-cultures, matrix-supported cultures, or other multicellular tissue‑like systems.
• Optimize culture conditions, media composition, growth factor cues, extracellular matrix conditions, differentiation timing, and co‑culture parameters.
• Validate model fidelity using readouts of cell identity, tissue architecture, maturation, and tissue‑specific function.
• Document protocols, experimental designs, model validation data, and decision criteria in a clear and reproducible manner.
• Communicate results, limitations, and technical risks to cross‑functional teams through written reports and oral presentations.

• PhD in a related discipline with 2+ years of experience
• MSc with 5+ years of experience
• BSc with 8+ years of experience

• PhD with 2+ years postdoctoral and/or industry experience in stem cell biology, developmental biology, tissue engineering, cell biology, bioengineering, molecular biology, organoid biology, or a related discipline.
• Hands‑on experience culturing and differentiating stem cells across relevant model systems
• Experience validating tissue architecture using methods such as immunostaining, confocal microscopy, flow cytometry, high‑content imaging, or functional assays.
• Experience optimizing media, growth factors, extracellular matrix conditions, differentiation timing, and co‑culture conditions for multicellular model systems.
• Familiarity with adult stem cell‑derived organoids, Lgr5‑positive stem cell biology, niche‑factor‑dependent epithelial systems, normal organoids, or patient‑derived organoid platforms is preferred but not required.
• Demonstrated scientific productivity and technical credibility through peer‑reviewed publications and patents
• Strong communication and collaboration skills and ability to work effectively as part of a multidisciplinary team.

As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well‑being.

Amgen is proud to have been recognized as one of Linked In Top 25 Companies in Canada for career growth.

The salary range for this position in Canada is $115,503 - $156,269 CAD.

In addition to the base salary, Amgen offers competitive and comprehensive Total Rewards Plans that…