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Lead Computational Scientist Driving Innovative Drug Discovery Efforts

Job in Calgary, Alberta, D3J, Canada
Listing for: Congruence Therapeutics
Full Time position
Listed on 2026-04-09
Job specializations:
  • Research/Development
    Research Scientist, Drug Discovery, Medicinal Chemist, Pharmaceutical Science/ Research
Salary/Wage Range or Industry Benchmark: 80000 - 100000 CAD Yearly CAD 80000.00 100000.00 YEAR
Job Description & How to Apply Below
Transform drug discovery by leveraging computational chemistry techniques in a flexible remote environment. Emphasize cutting-edge modeling and AI/ML to mentor a high-performing team and propel impactful therapies forward.

As a Senior Scientist in Computational Chemistry, you will be pivotal in shaping our drug discovery initiatives. Your expertise in physics-based modeling and advanced computational methods will guide the strategy across multiple programs. Collaborate with diverse teams to enhance drug development through data-driven insights and innovative methodologies.

Key Responsibilities:

• Lead computational chemistry efforts across discovery programs

• Optimize strategies for target assessment and hit identification

• Apply molecular dynamics and free energy calculations

• Collaborate with medicinal and AI teams on compound prioritization

• Mentor team members and contribute to scientific leadership

Requirements:

• PhD in computational chemistry or biophysics

• 10+ years in small molecule drug discovery

• Expertise in structure-based design and protein interactions

• Proficiency in machine learning frameworks like Py Torch

• Strong programming skills in Python/R and automation

Shape the future of drug discovery through innovative computational approaches and leadership, contributing directly to the advancement of transformative therapies.
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