Associate Scientist , RNAi

Company Description

Canary Cure Therapeutics is developing novel RNA-based therapeutics that target the endocannabinoid and energy expenditure systems to address obesity and related metabolic disorders. Our approach promotes the browning of white fat to increase metabolism and support sustainable weight loss. Unlike traditional therapies, our candidates are designed to preserve lean body mass, which is critical for long-term health outcomes. We also focus on convenient, less frequent dosing to improve adherence and quality of life for individuals with difficult-to-treat obesity.

Team members join a mission-driven environment dedicated to translating cutting-edge RNA science into clinically meaningful treatments.

The Associate Scientist, RNAi will work on-site full time in our Calgary, AB laboratory, contributing to the design, execution, and analysis of RNAi-based experiments supporting our therapeutic pipeline. Responsibilities include planning and performing in vitro studies to evaluate target knockdown, functional activity, and mechanism of action, as well as assisting with in vivo studies and sample analysis as needed. The role involves designing and optimizing experimental protocols, maintaining detailed electronic records, and interpreting data to inform project decisions.

The Associate Scientist will collaborate closely with cross-functional team members, present results in internal meetings, and support troubleshooting and continuous improvement of lab workflows. Additional duties include maintaining laboratory equipment, ensuring adherence to safety and quality standards, and contributing to documentation for internal reports and potential regulatory filings.

• Experience with RNAi or related RNA technologies (e.g., siRNA, shRNA, antisense oligonucleotides), including assay design and optimization.
• Hands‑on skills in molecular biology techniques such as RNA/DNA extraction, qPCR, PCR, cloning, and basic sequencing analysis.
• Cell culture proficiency, including maintenance of mammalian cell lines, transfection, and functional assays to assess gene and pathway modulation.
• Data analysis capabilities using common scientific software (e.g., Excel, Graph Pad Prism) and ability to interpret and clearly communicate experimental results.
• Bachelor’s or Master’s degree in Molecular Biology, Biochemistry, Cell Biology, Pharmacology, or a related life science discipline, or equivalent practical experience.
• Strong organizational skills, attention to detail, and the ability to manage multiple experiments and timelines in a fast‑paced environment.
• Effective written and verbal communication skills, with the ability to work collaboratively in an interdisciplinary, inclusive team setting.
• Familiarity with metabolic disease, obesity biology, or energy expenditure pathways is an asset, as is experience in an industry or translational research setting.