Post-Doctoral Fellowship in Structural Proteomics

APACE / Schriemer Lab

The Schriemer Lab is seeking a postdoctoral fellow with proteomics and mass spectrometry at the core of their expertise to help advance our structural proteomics program. This is an ideal opportunity for a chemist or biochemist who enjoys rigorous experimental work, strong method development, and working at the interface of chemistry, biology, and MS.

The successful candidate will play a central role in developing and applying crosslinking MS and HDX-MS workflows to study protein structure, interactions, and conformational dynamics in biologically relevant systems. The work will be embedded in a highly collaborative environment with active projects in immunology and neurobiology, where structural proteomics will help define molecular mechanisms and support ongoing discovery efforts.

• Advance and optimize crosslinking MS and HDX-MS workflows
• Design, execute, and interpret structural proteomics experiments
• Analyze MS data using appropriate proteomics and structural biology software tools
• Contribute to experimental planning, troubleshooting, and method refinement
• Collaborate with interdisciplinary teams in immunology and neurobiology

• PhD in chemistry, biochemistry
• Strong, demonstrated expertise in mass spectrometry-based proteomics
• Hands‑on experience with crosslinking MS, HDX‑MS, or closely related structural proteomics methods
• Proficiency with proteomics data analysis and associated bioinformatics tools/packages
• Strong laboratory skills, creativity, diligence, and a problem‑solving mindset
• Excellent communication skills and a collaborative approach