Cambridge, MA Operating Principal, Summit PBU

Summit, a Pioneering Business Unit within Flagship, is seeking an Operating Principal to help launch and scale our New Cos. You will work across one or more companies, leading operations and strategy, driving corporate development, and partnering closely with scientific leadership to translate breakthrough ideas into impact.

This role is ideal for an entrepreneurial leader who thrives in ambiguity, moves seamlessly between science and business, and is energized by building organizations from inception to growth.

• Lead strategy and operational planning in one or more New Cos.
• Drive corporate development initiatives, including partnerships, financings, and strategic alliances, as well as engagement with Board of Directors and other important stakeholders.
• Engage directly with scientists and company leaders to align technical progress with operational goals.
• Recruit, develop, and manage high-performing teams across functions.
• Partner with Flagship central teams (Finance, Talent, Legal/IP, HR) to bring best-in-class infrastructure to each company.
• Shape and execute operating and long-range plans, ensuring milestones are achieved on time and on budget.
• Build strong external relationships with investors, partners, and key opinion leaders.

Who you are: You are a dynamic operator and strategist who combines business leadership with scientific fluency. You thrive in fast-moving, entrepreneurial environments and are motivated by building organizations that harness novel science.

• 10+ years of experience in biotech, pharma, or life sciences strategy/operations; prior management consulting a plus.
• Proven success in strategic, operational, or corporate development leadership, ideally in early-stage biotech.
• Strong scientific acumen; able to quickly grasp novel science and translate it into plans and execution.
• Track record of building and motivating high-performing teams.
• Skilled communicator, able to influence and inspire across investors, partners, and internal teams.
• Expert problem solver; can bring order to chaos and iterate quickly to find solutions.
• Entrepreneurial, resilient, and hands‑on; able to adapt and execute with urgency; doesn’t mind rolling up sleeves and doing what needs to be done to move the ball forward.

You set a high bar for yourself and others, balancing precision with agility. You are curious, feedback-driven, and focused on constantly learning how to be the best version of yourself. You face challenges with grit and enthusiasm, while fostering collaboration, shared ownership, and pride in collective achievements.

Advanced degree in life sciences or business preferred (PhD, MD, MBA, or equivalent experience).

Cambridge, MA

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.

Flagship has been recognized twice on FORTUNE’s "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at

At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.

We are an equal opportunity employer
. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

We recognize that great candidates often bring unique strengths without fulfilling…