Vice President, Early Commercial Strategy

Overview

The Vice President of Early Commercial Strategy is a key senior function that will report to the SVP of Value & Pipeline commercialization. This role requires a visionary and results-drive leader to lead the strategic development and commercialization planning for our future product portfolio. This senior executive will play a critical role in shaping the company s long-term growth by identifying, evaluating, and prioritizing new product opportunities across the development pipeline and external innovation landscape.

This position is hybrid and will be primarily located at Alnylam headquarters in Cambridge, MA.

• Lead the end-to-end strategy for new products from early-stage development through commercialization readiness.
• Develop Target Product Profiles (TPPs), value propositions, and differentiation strategies in collaboration with R&D, Clinical, and Commercial teams.
• Drive disease area strategy, market segmentation, and product positioning based on unmet needs, competitive landscape, and evolving science.

• Collaborate closely with R&D, Regulatory, Medical Affairs, Business Development, and Marketing to ensure alignment on product vision and execution.
• Act as the commercial voice in development-stage governance forums and joint decision-making committees.

• Assess emerging trends, market dynamics, and competitive activity to inform pipeline decisions and portfolio prioritization.
• Evaluate strategic implications of evolving regulatory, pricing, and access landscapes globally.

• Contribute to portfolio optimization decisions including asset advancement, prioritization, or termination.
• Develop strategic lifecycle management plans to extend product value and market impact.

• Support business development in identifying and assessing external innovation opportunities.
• Collaborate on due diligence and integration strategies for in-licensed or acquired assets.

• Build / develop high performing team with the right capabilities to support Alnylam s next phase of growth

• BA / BS degree required; advanced scientific or business degree preferred
• 15+ years of biopharmaceutical or related experience, including global / international team responsibilities
• Experience in drug development and global product registration is a plus.
• Deep understanding of, and experience with, global and regional / country product commercialization in highly competitive markets. US market experience is a must.
• Ability to influence cross-functionally and drive alignment within the team, with peers and with senior management. Demonstrable level of executive presence.
• Ability to operate at both the strategic and tactical level, with ability to seamlessly move between both perspectives.
• Proactive "hands-on" individual with collaborative orientation, who manages matrix teams effectively, is very self-motivated and can smoothly establish and sustain strong working relationships within both internal stakeholders
• Decisive as well as collaborative. Can flex when needed and pursues data-driven decisions infuses with strong patient / physician / market-centricity

#LI-JD1 #LI-Hybrid

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The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k) with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks.

We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website:

We are the leader in RNAi therapeutics- a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people.

We re proud to be a globally recognized top employer, wherean authentic, inclusive…