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Director, Portfolio, Resourcing and Transformation

Job in Cambridge, Middlesex County, Massachusetts, 02140, USA
Listing for: AstraZeneca
Full Time position
Listed on 2026-10-12
Job specializations:
  • Business
    Operations Management, Change Management, Corporate Strategy, Business Analyst
Salary/Wage Range or Industry Benchmark: 159180.8 - 238771.2 USD Yearly USD 159180.80 238771.20 YEAR
Job Description & How to Apply Below
About the role

At AstraZeneca, we’re not afraid to do things differently. We’re building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening up new ways to work, pioneering ground-breaking methods and bringing cross-functional teams together.

Biologics Engineering (BE) and Oncology Targeted Discovery (OTD) are pivotal organizations of over 1,000 people building the AstraZeneca portfolio across Biopharmaceuticals, Oncology and Infectious Diseases. With our ambition of delivering 20 new medicines by 2030, we must decide clearly where to invest our scientific capacity, bring AI into how we discover and develop medicines, and build next-generation talent.

This role sits where science, portfolio and transformation meet. You will shape how our scientific capacity is allocated across therapy areas, and how we decide what to start, continue, slow or stop. And you will lead strategic and transformation projects, including bringing AI into how we work, with direct exposure to senior scientific and functional leadership.

The ideal candidate combines analytical difficulty with the standing to align senior leaders who do not report to them. They are as comfortable facilitating a decision between Vice Presidents as they are building the numbers that make that decision possible, and they hold both to the same standard.

You will be responsible for
  • Portfolio resource allocation and decision-making
  • Run the resource allocation process with leadership teams and therapy area representatives, starting in BE, with scope to extend across the wider organization over time.
  • Partner with the teams that produce resourcing actuals to improve existing reports, put the numbers in context, and turn them into inputs for decisions, so that allocation is decided rather than left to drift.
  • Ensure new work starts only where capacity exists or a named release is agreed, and that work is slowed or stopped through scheduled reviews and clear triggers, in partnership with the leaders who own those decisions.
  • Keep a clear record of allocation decisions and their expected effect on capacity and check the delivered effect against actuals.
  • Evolve the methodology, rules and forums as needs change and adapt them as new parts of the organization come into scope.
2. Strategic projects and transformation
  • Lead high-impact strategic projects for the leadership teams of BE and OTD, from framing the question through to recommendation and implementation.
  • Drive delivery of AI transformation programs: turn ambition into a clear roadmap, and set up the governance, cadence and reporting that keep it on track.
  • Bring senior leaders across departments behind shared priorities, and resolve interdependencies, resourcing questions and decisions as they arise.
  • Projects may also include operating model and organizational design choices, evaluating new capabilities and technology platforms, building investment cases, and portfolio and competitive analyses that inform where to focus.
  • Track delivery and value against agreed objectives, connect initiatives to portfolio and resourcing plans, and bring risks and decisions to sponsors early.
  • Assemble and lead cross-functional project teams and develop the people in them.
  • Build outcomes into ongoing ways of working and help what works spread across the wider organization.
3. Leadership and organizational effectiveness
  • Shape the governance cadence of the leadership teams you support agendas, pre-reads, and decisions and actions followed through to completion.
  • Track and report progress against goals and scorecard critical metrics, and flag risks to delivery early.
  • Own recurring operating processes end to end, so they run reliably without critical issue, and keep…
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