Medical Director, Oncology; Office Based - Cambridge, MA

Medical Director, Oncology (Office Based - Cambridge, MA)

Full-time

Zai Lab is a patient-focused, innovative, commercial-stage, global biopharmaceutical company based in China and the United States. We are dedicated to discovering, developing, and commercializing best-in‑class and first‑in‑class therapies that address medical conditions with significant unmet needs in oncology, immunology, neuroscience, and infectious disease. Guided by innovation and driven by purpose, our mission is to leverage our expertise and resources to make a lasting, positive impact on human health worldwide.

Zai Lab’s global team of 2,100 talented professionals includes industry leaders and professionals dedicated to advancing novel therapies to patients. With headquarters in Cambridge, Massachusetts, and Shanghai, and teams in the U.S., China and Europe, we collaborate across time zones to deliver meaningful impact where it’s needed most.

Founded in 2014 by Dr. Samantha Du, Zai Lab was purpose‑built to become a leading global biopharma, combining scientific innovation, operational scale, and strong execution. Our global pipeline features ZL‑1310, a DLL3 antibody‑drug conjugate (ADC) with best‑in‑class and first‑in‑class potential in small cell lung cancer, now in clinical trials. At the same time, our R&D team is progressing several other global programs into the clinic, including ZL‑1503, a bispecific IL‑13/IL‑31 antibody for atopic dermatitis, and ZL‑6201, an LRRC
15 ADC for solid tumors.

In China, we’ve earned a reputation as a partner of choice for leading global biopharmaceutical companies, leveraging our proven commercial infrastructure and clinical trial capabilities to accelerate market access to our innovative products. Due to its large population, China is the second largest pharmaceutical market in the world. Our unique business model combines in‑licensed assets with strategic partnerships, leveraging our in‑house research capabilities to build a regional portfolio of late‑stage, potential best‑in‑class and first‑in‑class therapies.

Today, with eight products on the market in China, we are delivering meaningful impact for patients and building opportunities for talented professionals to shape the future of medicine.

Zai Lab is publicly traded with dual‑primary listings on both the Nasdaq Stock Market and the Hong Kong Stock Exchange, underscoring our commitment to transparency, global reach, and long‑term growth.

The Medical Director will support the clinical development of oncology programs, focusing on the design, execution, and oversight of clinical trials. Responsibilities include independently contributing to and executing on the clinical strategy, serving as Medical Monitor, supporting regulatory submissions, and collaborating and leading cross‑functional teams. The role provides scientific and medical input to ensure the successful conduct of clinical trials and advancement of oncology assets.

This role reports to the VP, Clinical Development, Oncology and is based in our Cambridge, MA office.

• Clinical Trial: Provide medical expertise to support the leading physician/scientist for the design and execution of oncology clinical trials. Collaborate with clinical operations to ensure trials are conducted in alignment with scientific objectives, patient safety standards, and regulatory requirements.
• Medical Monitoring: Serve as Medical Monitor for assigned clinical trials, ensuring patient safety, protocol compliance, and medical oversight. Review safety data, participate in data monitoring activities, and act as the primary medical contact for study teams and investigators.
• Cross‑functional
  
  Collaboration:
  
  Work with regulatory affairs, clinical operations, pharmacovigilance, biostatistics, medical affairs, and commercial teams to align clinical and business objectives, often across multiple time zones.
• External Representation: Represent Zai Lab in interactions with investigators, key opinion leaders, regulatory authorities, and external collaborators.
• Data Analysis & Interpretation: Analyze clinical trial data and real‑world evidence to identify trends, assess efficacy and safety signals, and…