Associate Medical Director​/Medical Director

Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform. Korro is generating a portfolio of differentiated programs that are designed to harness the body’s natural RNA editing process to effect a precise yet transient single base edit. By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability.

Using an oligonucleotide-based approach, Korro expects to bring its medicines to patients by leveraging its proprietary platform with precedented delivery modalities, manufacturing know-how, and established regulatory pathways of approved oligonucleotide drugs. Korro’s lead program is for Urea Cycle Disorders. Korro is based in Cambridge, Massachusetts. For more information, visit

We are collaborative and united by a common mission. We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases. Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization. They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work.

Join us as we redefine what's possible in genetic medicine and work to make a lasting impact on human health.

Korro Bio is seeking an Associate Medical Director or Medical Director to provide medical leadership for our clinical programs, with initial focus on KRRO-121, our Phase 1 program for hyperammonemia in urea cycle disorders, and its potential expansion into hepatic encephalopathy. Reporting to the Vice President, Clinical Development, this physician will act as the medical lead and medical monitor for first-in-human and early patient studies, lead the clinical content of protocols and regulatory documents, and own medical judgment on dose escalation, safety review, and study design.

Level will be set by depth of industry clinical development experience. The ideal candidate is a physician with early-phase development experience who is comfortable making and owning medical decisions in a small, fast-moving team and motivated to bring a new class of genetic medicines to patients.

• Serve as medical monitor for assigned studies, from first-in-human single and multiple ascending dose cohorts in healthy volunteers through early patient studies in urea cycle disorders and hepatic encephalopathy, including eligibility questions, medical review of protocol deviations, and ongoing review of safety and laboratory data.
• Lead medical assessment of adverse events, serious adverse events, and laboratory abnormalities, including causality, expectedness, dose-limiting toxicity determinations, and application of protocol stopping and dose modification rules, in partnership with Drug Safety and Pharmacovigilance.
• Serve on Safety Review Committees and support dose escalation and cohort progression decisions through integrated review of safety, pharmacokinetic, and pharmacodynamic data, including plasma ammonia and related biomarkers.
• Author and review clinical documents, including protocol concepts, protocols and amendments, informed consent forms, clinical sections of the Investigator’s Brochure, safety monitoring plans, and clinical study reports.
• Author clinical sections of regulatory submissions and health authority interactions, including INDs, CTAs, briefing documents, Development Safety Update Reports, and…