Director, Domestic Tax

Scholar Rock is delivering muscle-targeted breakthroughs to transform the treatment of spinal muscular atrophy (SMA) and other rare neuromuscular diseases where muscle atrophy remains a critical unmet need.

As a global leader in myostatin biology, a field focused on proteins that regulate muscle mass, the biopharmaceutical company is named for the visual resemblance of a scholar rock to protein structures.

Our commitment to unlock fundamentally different treatment approaches is powered by broad application of a proprietary platform, which has developed novel monoclonal antibodies to modulate protein growth factors with extraordinary selectivity. Scholar Rock works every day to create new possibilities for patients through its highly innovative anti-myostatin program, including opportunities in additional rare neuromuscular diseases. Learn more about our neuromuscular franchise at and follow @Scholar Rock on X and on Linked In.

Summary of Position:

We are looking for an experienced Domestic Tax professional to join our growing tax team. The Director, Domestic Tax will report to the Vice President, Tax and can be based in our Cambridge, MA or Miami, FL office. In this role, you will lead Scholar Rock’s U.S. federal, state, and local direct tax accounting, compliance, planning, and controversy activities, as well as U.S. sales and use tax and other domestic indirect taxes.

The role owns the domestic components of the quarterly and annual income tax provision, the consolidated U.S. federal income tax return, multistate compliance, domestic audit defense, and U.S. tax planning. The Director, Domestic Tax also serves as the overall Tax workstream lead for the ERP implementation and related finance transformation initiatives.

• Lead the U.S. federal and state components of the quarterly and annual income tax provision under ASC 740.
• Oversee current and deferred tax expense, domestic tax balance sheet accounts, effective tax rate items, tax account reconciliations, return-to-provision calculations, and provision-to-return adjustments.
• Own deferred tax calculations for net operating losses, research expenditures under Section 174, R&D and orphan drug credits, Section 163(j), fixed assets, stock-based compensation, clinical and compensation accruals, and other domestic temporary differences.
• Lead domestic valuation allowance and uncertain tax position analyses and maintain complete, audit-ready support.
• Support income tax disclosures, external audit requests, and management reporting related to domestic tax matters.

• Own the consolidated U.S. federal income tax return, including work papers, elections, disclosures, estimates, extensions, payments, and filing governance.
• Incorporate U.S. international calculations and information returns as prepared by advisors or other members of the Tax team.
• Lead state and local income and franchise tax compliance, including combined, consolidated, unitary, and separate-company filings.
• Review nexus, apportionment, state modifications, filing methodologies, tax attributes, credits, incentives, and payment requirements.
• Maintain the domestic compliance calendar, data collection process, review standards, and oversight of external and co-sourced providers.

• Identify and implement U.S. federal and state tax planning opportunities aligned with the Company's strategy and risk profile.
• Advise on the U.S. tax treatment of R&D, clinical trials, research credits, Section 174 capitalization, stock-based compensation, executive compensation, manufacturing incentives, product launches, and commercial operations.
• Analyze licensing, collaboration, milestone, royalty, co-development, product acquisition, and commercialization arrangements from a domestic tax perspective.
• Monitor U.S. federal and state legislative developments, assess financial and operational impacts, and lead implementation.
• Prepare technical memoranda supporting material domestic tax positions and transactions.

• Lead U.S. federal and state income and franchise tax examinations, notices, information requests, protests, appeals, settlement negotiations, and litigation support.
• Coordinate with the Vice President, Tax on examinations involving transfer pricing or U.S. international tax matters.
• Ensure examination outcomes are reflected in the provision, returns, forecasts, controls, and process…