Director, Clinical Research-CNS

Overview

Alnylam Pharmaceuticals is seeking an imaginative physician drug developer, with flexibility and confidence to work across diseases within the neurology therapeutic area. This role includes the opportunity to provide clinical leadership in developing RNAi therapeutics in Alnylam's expanding CNS portfolio, which spans from rare genetic to common diseases.

The successful candidate's primary role will be one of the clinical study leads working within the Alzheimer's portfolio. The Director, Clinical Research, will report directly into the program clinical development strategy lead who provides the clinical research oversight of the program. Director, Clinical Research, is expected to play a leading and influencing role in the overall clinical development strategies and drive progress and operational excellence of clinical trial(s).

This work will also involve extensive consultation and collaboration with external experts. It is expected that additional opportunities will arise to lead bench‑to‑bedside early phase clinical development programs. The Director, Clinical Research, will work in a matrix organization across Regulatory, Biostatistics, Clinical Operations, Preclinical, Commercial & Quality Assurance teams to ensure fully harmonized and integrated development strategies. The Director, Clinical Research, will be a key Alnylam Development spokesperson at external meetings, including regulatory interactions and scientific meetings.

• Be a subject matter expert for the relevant disease area(s)
• Be the strategic leader providing a strong, clear voice for the clinical program
• Develop creative but realistic approaches to drug development and lead clinical efforts towards global regulatory approvals
• Oversight of trial conduct and safety
• Collaborate closely with Preclinical, Regulatory Affairs and Medical Affairs to ensure tight strategic integration of product development plans.
• Be accountable via Clinical Research and Operations for all relevant timelines and deliverables.
• Supervise closely all major written deliverables (regulatory submissions, original articles, abstracts), and presentation materials.
• Be responsible for final review and sign off with respect to all controlled documents including protocols, investigator brochures, and informed consent forms.
• Influence internal and external audiences in a high impact, highly visible fashion

A highly driven, dynamic, engaged and accomplished physician‑scientist with experience and insight will thrive in this role. Specific qualifications include:

• MD with strong research background or MD PhD with best of class clinical and/or research training as shown through research support and peer‑reviewed publications.
• Board Certification (or equivalent) or specialist training in neurology is desirable
• 3+ years industry experience or equivalent clinical academic research experience
• Sound scientific and clinical judgment
• Familiarity with concepts of clinical research and clinical trials, including biostatistics, and regulatory agency organization, guidelines, and practices
• Ability to effectively present ideas and document complex medical/clinical concepts in both written and oral communication
• History of critical thinking and problem solving while exhibiting superior judgment and a balanced, realistic understanding of issues
• Outstanding leadership and collaboration skills working within a matrix environment
• Thrives in highly entrepreneurial biotech environment and embraces Alnylam's culture of science, passion and urgency.

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The pay range reflects the full‑time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short‑term incentive award (e.g., bonus or sales incentive) and an annual long‑term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well‑being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a…