Scientist, In Vivo Pharmacology, Neuroscience

At Bristol Myers Squibb, our employees often ask, "Who are you working for?" - a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits.

This is work that transforms the lives of patients, and the careers of those who do it.

The Neuroscience TRC is committed to the development of transformational therapeutics for patients with neurodegenerative, neuromuscular and neuropsychiatric diseases. A network of internal and external partnerships across neurodegenerative and neuropsychiatric diseases and treatment modalities (small molecules, biologics and genetic medicines) supports our ambition to become leaders in neuroscience. Internal research focuses on causal human biology, matching therapeutic modality to molecular mechanism, and translational discovery enabling a rapid path to clinical proof-of-concept.

• Performs and directs in vivo pharmacology studies in mice, inclusive of in-life dosing (IV, SC, IP, PO, ICV), tissue collection, and tissue processing
• Performs and analyzes pharmacodynamic (PD) and efficacy readouts, including mRNA/protein expression levels, neuropathology, transcriptomics, and physiology.
• Manages in vivo studies conducted at contract research organizations (CROs)
• Serves as an in vivo pharmacology representative on program and platform teams

• Bachelor's Degree
  • 5+ years of academic and / or industry experience

• PhD in Neuroscience or related field is required.
• Expertise and practical experience in one or more of the following:
  • Neurodegenerative disease, such as Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease, particularly with respect to animal modeling
  • Neuromuscular disease, such as amyotrophic lateral sclerosis (ALS) and muscular dystrophies, particularly with respect to animal modeling
  • RNA biology and splice modulation
  • Genetic medicines, particularly the delivery of siRNAs and/or ASOs across the blood-brain barrier (BBB)
• Extensive mouse handling experience, including common dosing routes and tissue collection from central nervous system (CNS) and peripheral tissues required
• Proficiency in standard molecular biology, biochemical, immunohistochemical, and/or muscle physiology assays required
• Experience with rodent stereotaxic surgery
• Familiarity with in vivo bioluminescence imaging
• Familiarity with transcriptomics and/or proteomics
• Experience working with contract research organization (CROs)
• Strong organizational and communication skills
• Ability to work independently and as part of a team
• Detail-oriented with a commitment to scientific rigor and reproducibility
• Adaptability in a fast-paced, collaborative research environment

Cambridge Crossing: $129,640 - $157,096

The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully - carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws.

Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans - including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).

U.S.

-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.

Non-exempt employees, Rayze Bio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.

Depending on eligibility, employees may also have access to additional time-off benefits,…