Senior Principal Scientist Computational Multiomics Precision Measures

Job Function

Data Analytics & Computational Sciences

Bioinformatics

Scientific/Technology

Cambridge, Massachusetts, United States of America, San Diego, California, United States of America, Spring House, Pennsylvania, United States of America

At Johnson & J​ohnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

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Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science‑based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Our Neuroscience team tackles the world’s toughest brain health challenges including multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, myasthenia gravis, epilepsy, major depressive disorder, bipolar disorder, schizophrenia, and autism. This patient-focused team helps address some of the most complex diseases of our time.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

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Our Neuroscience Precision Measures team leads in the development of transformational medicines for Neurodegeneration, Neuropsychiatry and Ophthalmology by advancing Precision in Measurement. You can influence the future success of our Precision Neuroscience portfolio by partnering along the pipeline to ensure measurement discovery and development strategies are deeply aligned. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

We are searching for a Senior Principal Scientist, Computational Multiomics, Precision Measures
, to be in either Cambridge, MA;
Spring House, PA;
La Jolla, CA United States of America or Beerse, Antwerp, Belgium, and follows a hybrid schedule of three days in the office and two days remotely per week.

Please note that this role is available across multiple countries and may be posted under different requisition numbers to comply with local requirements. While you are welcome to apply to any or all of the postings, we recommend focusing on the specific country(s) that align with your preferred location(s).

Requisition Number: R-010385

Requisition Number:
R011778

• The candidate will apply large scale multiomics and genetic capabilities to support precision medicine from discovery through development in our Neuroscience portfolio.
• Collaborate closely with the Molecular Biomarker leads in Precision Measures and pipeline program teams to drive in‑silico identification of target engagement and pharmacodynamic biomarker candidates.
• Partner with Neuroscience Discovery on the evaluation of target opportunities from the perspective of cutting‑edge genetics, bioinformatics, biosignatures, brain biology, and mechanism, drawing upon a combination of internal and external human data resources and integrative analytics.
• Drive evidence generation and partnership strategies for markers of disease heterogeneity, progression, and treatment response from data sources including clinical trials, precompetitive consortia, academic collaborations or population biobanks. This candidate will be a thought leader on the use of computational tools and analytic approaches in this setting.
• Engage with Clinical Development, Global Regulatory Affairs, Data Science & Digital Health, Patient Reported Outcomes, Statistics to contribute to holistic measurement plans (across molecular, imaging, digital, clinical and other measures) for our compounds in development.
• Contribute to a purpose driven culture in which decisions and actions are strategically informed by patient, customer and employee needs by…