Senior Director, R&D Data Science & Digital Health – Ophthalmology

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

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Job Function: Data Analytics & Computational Sciences

Job Sub Function: Data Science Portfolio Management

Job Category: People Leader

All Job Posting Locations: Cambridge, Massachusetts, United States of America;
San Diego, California, United States of America;
Spring House, Pennsylvania, United States of America;
Titusville, New Jersey, United States of America

Job Description: Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at

Johnson & Johnson Innovative Medicine is recruiting for Senior Director, R&D Data Science & Digital Health – Ophthalmology
. This position can be located in one of our office locations in either Cambridge, MA (preferred), Spring House, PA, Titusville, NJ, or San Diego, CA. May require approximately 25% domestic and international travel.

We are seeking an experienced and visionary Senior Director to lead our data science and digital health strategy for ophthalmology. This role will shape and execute innovative approaches leveraging multiomics, digital health technologies, artificial intelligence, and clinical/real-world evidence (RWE) to accelerate drug discovery, development, and patient impact. You will partner closely with Neuroscience Therapeutic Area, Clinical Development, Quantitative Sciences, Regulatory and Patient Reported Outcomes as well as external collaborators to drive a precision neuroscience agenda.

This position offers the opportunity to transform how we understand disease biology, identify novel endpoints, stratify patients, and deliver better outcomes for people living with ophthalmic disorders.

• Define and execute the data science and digital health strategy for ophthalmology, integrating computational biology, AI/ML, digital health, and clinical/RWE insights.
• Drive the application of multiomics (genomics, proteomics, transcriptomics, metabolomics, etc.) and integrative analytics to uncover disease mechanisms, biomarkers, and novel targets.
• Lead the development, validation, and regulatory engagement of digital tools and novel endpoints to enhance clinical trial design, patient monitoring, and care pathways.
• Champion the use of machine learning, deep learning, generative and agentic AI to accelerate patient stratification, disease modeling, and translational discovery.
• Partner with clinical development and medical affairs to integrate RWE into evidence generation, supporting trial optimization, regulatory submissions, and real-world impact assessment.
• Build strong cross‑functional and external collaborations with academic groups, technology providers, regulators, and consortia to position the company at the forefront of data‑driven science.
• Recruit, develop and inspire a diverse team of digital health scientists, RWE experts and computational scientists to deliver on strategic initiatives.

• Advanced degree (PhD, MD or equivalent) in neuroscience / quantitative sciences such as biomedical engineering, data science, biostatistics, computational biology or a related field is required.
• 10+ years of relevant industry or academic experience, with proven leadership in applying data‑driven methods to drug discovery and development is required.
• 7+ years of experience as a people manager is required.
• Experience in clinical development with demonstrated expertise in ophthalmology preferred.
• Excellent communication…