Senior Director, Global Trial Strategy & Operations

Role Overview

The Senior Director, Global Trial Strategy & Operations is a strategic operational leader responsible for driving disciplined execution, portfolio-level planning, and operational excellence across the Cardiovascular and TTR portfolio. This role reports directly to the Vice President, Study Management and works in close partnership to design, and/or operationalize strategic priorities, ensure alignment to critical path, and elevate delivery standards across studies.

The Senior Director influences execution through operational strategy, planning frameworks, portfolio insights, prioritization, governance, and cross-functional alignment. The role partners closely with study and program leadership to ensure operational strategies are robust, documented, actively managed, and informed by risk.

The role may represent the portfolio and VP, Study Management in selected leadership forums, enabling alignment, continuity of strategy, and visibility to progress and risks. Additionally, the Senior Director contributes to organizational evolution by developing standards, best practices, and processes that enhance scalability, quality, and trial efficiency across the portfolio.

The Senior Director, Global Trial Strategy & Operations ensures high-quality execution across programs through strategic influence, operational frameworks, and portfolio-level visibility. He/she partners with program, study, and functional leaders to drive disciplined planning, milestone transparency, risk mitigation, and alignment to strategic priorities.

Reporting directly to the VP, Study Management, the Senior Director works in close collaboration to operationalize strategic priorities across the Cardiovascular and TTR portfolio. Acting on behalf of the VP when delegated, he/she may represent the portfolio in leadership and governance settings to reinforce alignment and support informed, timely decision-making.

He/she may/may not manage direct reports but drives impact by influencing delivery and team effectiveness through clarity of expectations, strategic frameworks, and cross-functional alignment. He/she ensures that teams operate with rigor, that plans are well defined and maintained, and that performance insights drive continuous improvement across the portfolio.

He/she contributes to the continued evolution of Clinical Operations and GTSO by participating in and leading initiatives, establishing scalable practices, operating models, and delivery standards that enhance efficiency, quality, consistency, and inspection readiness.

He/she will work closely with CRO partners to ensure aligned execution against scope of work, proactive risk management, and focus on critical path and priority deliverables. This includes developing best practices for vendor oversight, communication cadence, issue escalation, and performance monitoring across the Cardiovascular and TTR portfolio.

The Senior Director will also assist in financial oversight across programs, including budget tracking, investment planning cycles, annual operating planning, and long-range planning. Additionally, he/she will partner closely with other clinical operations functions-including SM&H, GTO, CPS, and cross-functional program teams-to ensure alignment, process improvements, and delivery excellence.

• Partner across Clinical Operations, study teams, and cross-functional partners to drive strategic operational planning, including defining approaches, execution assumptions, timelines, risk management strategies, and delivery frameworks.
• Develop portfolio-level tracking mechanisms, dashboards, KPIs, and performance analytics to support transparency and data-driven decision-making.
• Drive prioritization and scenario planning across the Cardiovascular and TTR portfolio, ensuring alignment to critical path and effective deployment of resources.
• Represent the portfolio in leadership and governance forums, when delegated, ensuring continuity of strategy, alignment, and clarity of decision pathways.
• Develop, institutionalize, and continuously refine best practices, operating models, playbooks, and standards that reinforce planning rigor, predictable execution, and operational excellence.
• Partner with study and program leaders to ensure operational plans are documented, actively managed, and responsive to risks, external changes, and portfolio dependencies.
• Collaborate with cross-functional leaders to support operational readiness, including inspection readiness, vendor oversight frameworks, and compliance.
• Establish and evolve operating rhythms and governance structures that streamline communication, clarify accountability, and enable timely decisions across programs.
• Serve as a strategic thought partner to elevate execution focus, challenge assumptions, integrate lessons learned, and support continuous improvement.
• Partner closely with CROs and external vendors to ensure proactive execution, scope adherence, and high-quality delivery while…