Scientist, Protein Production and Screening

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At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.

We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why we’ve invested in growing our footprint and expanding our R&D space in Cambridge, with a primary focus on additional state-of-the-art lab space.

The US Structural Biology Center of Excellence (CoE) at GSK, a new joint Vaccines and Pharma Center, will be established in Cambridge, MA in 2025. The mission of the CoE is to apply the full range of structural biology, protein biochemistry, and computational tools to design vaccine antigens, RNAs, delivery systems, and formulations for vaccines as well as to design antibodies, biologics, and small molecules.

We’re looking for a passionate and highly motivated scientist to join the CoE. As a crucial member of our team you will deploy your scientific knowledge in recombinant protein production from mammalian, bacterial and/or insect expression systems. We are eager to see your contributions to our candidate screening platform to increase throughput and improve the depth of data available. The position will require active collaboration with diverse team to work together and address key challenges.

You will be expected to maintain our laboratory environment and introduce new methods/protocols related to your specific area of expertise. Your time-management and organization skills will be highly valued. This position offers you the opportunity to actively contribute to multiple pipeline projects simultaneously and directly impact the progression of our preclinical medicine and vaccine candidates. You will need to anticipate problems, proactively seek solutions, and balance competing priorities to be successful.

This role interacts directly with both upstream and downstream counterparts to enable smooth communication and hand-off of materials. You will also have the opportunity to interact with scientists based in other centers and countries, ensuring that you can access the most up-to-date knowledge and capabilities to efficiently fulfill your missions.



Key Responsibilities :

• Propose, implement, maintain, and deliver existing and/or new capabilities for the high-throughput, small-scale recombinant protein production.
• Propose and implement lab automation solutions to enable rapid screening and data presentation to drive project decisions.
• Collaborate with the protein expression, protein purification, molecular design, biophysics, and structural biology teams to ensure the correct prioritization of samples.
• Deliver high quality data with appropriate control experiments and documentation
• Interpret the results of experiments and update protocols accordingly.
• Keep current with the latest developments and techniques in the field.
• Ensuring safety procedures and regulations are followed in the laboratory.
• Present research findings and updates in internal reports, project meetings, and external scientific meetings when appropriate.

• BSc or MSc in protein biochemistry, cell biology, biology, molecular biology or related field.
• BS and 4+, or MSc and 2+ years hand-on experience, preferably in an industrial research environment, national lab and/or other protein production core facility.
• One or more years of experience with lab automation techniques including small scale protein expression, small scale protein purification, analytical techniques in 96 and/384 well plates.
• One or more years of experience purifying protein from mammalian cell culture including HEK
  293 and/or CHO cell lines.
• One or more years of experience in the operation and maintenance of AKTA systems.

• PhD in…