Research Scientist

The Opportunity:

The Gene and Cell Therapy Institute (GCTI) is a newly created system-wide Institute under Mass General Brigham. The Institute will foster a world-class gene and cell therapy program that will leverage ongoing, groundbreaking scientific research efforts across the MGB system.

The mission of GCTI is to bring together the community of MGB investigators which can utilize gene and cell therapy platforms to achieve their scientific and clinical goals and improve the health of patients.

The Institute will differentiate itself by harnessing the exceptional strengths of clinician scientists, the large and unique patient population, and major discoveries throughout the hospital system to propel MGB as the leader in Gene & Cell therapies.

The Abudayyeh-Gootenberg Gene Editing lab at the Mass General Brigham Gene and Cell Therapy Institute is seeking a talented AI Scientist and Engineer to join the Mass General Brigham Gene and Cell Therapy Institute. This role will work across multiple groups within the institute, including the Abudayyeh-Gootenberg lab, gene editing core, and RNA core. The successful candidate will contribute to developing AI solutions for gene and cell therapy, support general computational efforts, and help shape strategic directions for the institute.

This is a unique opportunity to work at the intersection of cutting-edge technology development and groundbreaking biomedical research. You will be part of a dynamic team focused on advancing gene therapy, cell therapy, stem cell biology, regenerative medicine, and biomanufacturing, through the application of advanced machine learning approaches. Your work will directly contribute to our understanding of large-scale data across different fields and the development of novel technologies and therapeutics.

As an AI Scientist and Engineer in our institute, you will play a crucial role in developing models to understand and model large amounts of biological data, including single-cell, genomics, and transcriptomic data. This work will ultimately yield predictive and generative models that can program biology and enable new technologies and therapeutics.

Your position will also be highly collaborative, involving close interaction with experimental scientists, computational biologists, and other researchers across the institute and labs. We actively encourage creativity and leadership from our computational experts, and you will have the opportunity to lead multiple projects within the institute. This role offers the exciting prospect of being at the forefront of AI applications in gene and cell therapy, with the potential to make significant contributions to the field.

• Opportunity to work at the forefront of AI applications in gene and cell therapy
• Collaboration with world-class researchers and cutting-edge technologies
• Access to state-of-the-art facilities and resources
• Potential to contribute to groundbreaking discoveries in regenerative medicine
• Supportive and innovative work environment that encourages creativity and leadership

• Ph.D. in Computer Science, Computational Biology, Bioinformatics, or a related field required
• Previous research experience 5-7 years required

• Strong programming skills and experience with machine learning frameworks
• Expertise in processing and analyzing single cell data
• Familiarity with deep learning models and their applications in biological data
• Experience with large-scale data management and computing clusters
• Knowledge of molecular biology, stem cell biology, gene therapy, and/or cell therapy is highly desirable
• Excellent communication skills and ability to collaborate with multidisciplinary teams
• Strong organizational and project management abilities
• Ability to manage small teams toward high-level goals and priorities
• Demonstrated ability to work in a fast-paced, dynamic research environment

• Trains/mentors study staff
• Mentor a team of data analysts in statistical analysis, study design, and coding
• Oversee progress across multiple research and evaluation projects
• Identify, assimilate, and synthesize data needed for computer models and manage databases related to statistical and software tools
• Work closely with cross-functional teams (analytical chemistry, sensory, applications & flavor creation) to achieve desired results
• Lead internal encapsulation science research program as well as external research collaborations
• Design, execute, and interpret research experiments
• Analyze and present data at internal and external meetings
• Perform other duties as assigned
• Comply with all policies and standards

Mass General Brigham Incorporated is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information,…